Seroprevalence of Bordetella pertussis antibodies in Flanders (Belgium)

被引：24

作者：

Van der Wielen, M

Van Damme, P

Van Herck, K

Schlegel-Haueter, S

Siegrist, CA

机构：

[1] Univ Instelling Antwerp, WHO Collaborat Ctr Prevent & Control Viral Hepati, Ctr Evaluat Vaccinat, Dept Epidemiol & Social Med, B-2610 Wilrijk, Belgium

[2] Univ Geneva, WHO Collaborat Ctr Neonatal Vaccinol, Dept Pathol & Paediat, Geneva, Switzerland

来源：

VACCINE | 2003年 / 21卷 / 19-20期

关键词：

pertussis antibodies; Bordetella pertussis; pertactin; pertussis toxoid; age-specific prevalence;

D O I：

10.1016/S0264-410X(03)00062-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To determine age-dependent pertussis immune response in the Flemish population, antibody levels to pertactin (PRN), pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in serum samples from 1622 healthy 1-100-year-old subjects. For anti-PRN and anti-PT antibodies, peaks in GMTs were seen in infancy and again in the 10-15-year age group. After age of 20 years, anti-PRN GMT declined rapidly over a decade, followed by a slower decline. Anti-FHA GMT tended to rather increase progressively with age. These data confirm waning of vaccine-induced antibody levels and suggest pertussis resurgence during adolescence and young adulthood. These results support a pertussis booster vaccination policy for adolescents and adults. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2412 / 2417

页数：6

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