Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

被引：69

作者：

Siravegna, Giulia ^{[1
,2
,3
]}

Bardelli, Alberto ^{[1
,2
]}

机构：

[1] Univ Turin, Dept Oncol, I-10060 Turin, Italy

[2] IRCCS, FPO, Candiolo Canc Inst, I-10060 Turin, Italy

[3] FIRC Inst Mol Oncol IFOM, I-20139 Milan, Italy

来源：

GENOME BIOLOGY | 2014年 / 15卷 / 08期

关键词：

CIRCULATING NUCLEIC-ACIDS; PLASMA DNA; ACQUIRED-RESISTANCE; CANCER-PATIENTS; MICROSATELLITE ALTERATIONS; SERUM DNA; MUTATIONS; ORIGIN; QUANTIFICATION; GENE;

D O I：

10.1186/s13059-014-0449-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA fragments released from cancer cells into the blood can be used to generate molecular profiles of tumors. Non-invasive 'liquid biopsies' can be used to monitor minimal residual disease and detect the emergence of drug resistance.

引用

页数：6

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