Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

被引：68
作者：
Siravegna, Giulia [1 ,2 ,3 ]
Bardelli, Alberto [1 ,2 ]
机构：
[1] Univ Turin, Dept Oncol, I-10060 Turin, Italy
[2] IRCCS, FPO, Candiolo Canc Inst, I-10060 Turin, Italy
[3] FIRC Inst Mol Oncol IFOM, I-20139 Milan, Italy
来源：
GENOME BIOLOGY | 2014年 / 15卷 / 08期
关键词：
CIRCULATING NUCLEIC-ACIDS; PLASMA DNA; ACQUIRED-RESISTANCE; CANCER-PATIENTS; MICROSATELLITE ALTERATIONS; SERUM DNA; MUTATIONS; ORIGIN; QUANTIFICATION; GENE;
D O I：
10.1186/s13059-014-0449-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
DNA fragments released from cancer cells into the blood can be used to generate molecular profiles of tumors. Non-invasive 'liquid biopsies' can be used to monitor minimal residual disease and detect the emergence of drug resistance.
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页数：6
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