Calibration of a microdialysis sensor and recursive glucose level estimation in ICU patients using Kalman and particle filtering

被引：3

作者：

Charalampidis, Alexandros C. ^{[1
]}

Pontikis, Konstantinos ^{[2
]}

Mitsis, Georgios D. ^{[3
,4
]}

Dimitriadis, George ^{[5
,6
]}

Lampadiari, Vaia ^{[5
,6
]}

Marmarelis, Vasilis Z. ^{[7
]}

Armaganidis, Apostolos ^{[2
]}

Papavassilopoulos, George P. ^{[1
]}

机构：

[1] Natl Tech Univ Athens, GR-10682 Athens, Greece

[2] Univ Athens, Sch Med, Dept Crit Care 2, GR-10679 Athens, Greece

[3] Univ Cyprus, Dept Elect & Comp Engn, KIOS Res Ctr Intelligent Syst & Networks, CY-1678 Nicosia, Cyprus

[4] McGill Univ, Dept Bioengn, Montreal, PQ, Canada

[5] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Internal Med 2,Res Inst, GR-10679 Athens, Greece

[6] Univ Athens, Sch Med, Attikon Univ Hosp, Ctr Diabet, GR-10679 Athens, Greece

[7] Univ So Calif, Los Angeles, CA USA

来源：

BIOMEDICAL SIGNAL PROCESSING AND CONTROL | 2016年 / 27卷

关键词：

Continuous glucose monitoring systems; Artificial Pancreas; Kalman filtering; Particle filtering; Stochastic models; Intensive care unit; NONLINEAR-SYSTEMS; MINIMAL-MODEL; INSULIN;

D O I：

10.1016/j.bspc.2015.11.003

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper deals with the estimation of glucose levels in ICU patients by the application of statistical filter theory to the data provided by a commercial continuous glucose monitoring system using a microdialysis sensor. Kalman and particle filtering are applied to simple models of the glucose dynamics. The particle filter enables the joint filtering and calibration of the sensor. The results show that the proposed filters lead to significant reduction in the estimation error with computational cost well within the capabilities of modern digital equipment. Additionally, the filters can be used for the automatic recognition of sensor faults. These results show that suitable filters can help in the construction of an artificial pancreas. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：155 / 163

页数：9

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