Long COVID: cognitive complaints (brain fog) and dysfunction of the cingulate cortex

被引:139
作者
Hugon, Jacques [1 ,4 ]
Msika, Eva-Flore [4 ]
Queneau, Mathieu [2 ]
Farid, Karim [3 ]
Paquet, Claire [1 ]
机构
[1] Univ Paris, Lariboisiere Hosp, AP HP, Ctr Cognit Neurol,Inserm 1144, Paris, France
[2] North Cardiol Ctr, Dept Mol Imaging, St Denis, France
[3] CHU Ft de France, Dept Mol Med, Fort De France, Martinique, France
[4] Memory Clin, 16 Rue Teheran, F-75008 Paris, France
关键词
Long COVID; Cognitive involvement; Cingulate cortex;
D O I
10.1007/s00415-021-10655-x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Many patients who have suffered from acute COVID infections have long-lasting symptoms affecting several organs including the brain. This long COVID status can include "brain fog" and cognitive deficits that can disturb activities of daily living and can delay complete recovery. Here, we report two cases of neurological long COVID with abnormal FDG PET findings marked by hypometabolic regions of the cingulate cortex.
引用
收藏
页码:44 / 46
页数:3
相关论文
共 11 条
[1]  
Boeve Bradley F, 2012, Parkinsonism Relat Disord, V18 Suppl 1, pS41, DOI 10.1016/S1353-8020(11)70015-3
[2]   How COVID-19 Affects the Brain [J].
Boldrini, Maura ;
Canoll, Peter D. ;
Klein, Robyn S. .
JAMA PSYCHIATRY, 2021, 78 (06) :682-683
[3]  
Coutinho Artur M.N., 2015, Dement. neuropsychol., V9, P385, DOI 10.1590/1980-57642015DN94000385
[4]   An interactive web-based dashboard to track COVID-19 in real time [J].
Dong, Ensheng ;
Du, Hongru ;
Gardner, Lauren .
LANCET INFECTIOUS DISEASES, 2020, 20 (05) :533-534
[5]   Neurological associations of COVID-19 [J].
Ellul, Mark A. ;
Benjamin, Laura ;
Singh, Bhagteshwar ;
Lant, Suzannah ;
Michael, Benedict Daniel ;
Easton, Ava ;
Kneen, Rachel ;
Defres, Sylviane ;
Sejvar, Jim ;
Solomon, Tom .
LANCET NEUROLOGY, 2020, 19 (09) :767-783
[6]   PET Hypometabolism of the Prefrontal-Cingulate Cortices in Internet Gaming Disorder [J].
Kim, Sun Ki ;
Jeong, Hyeonseok ;
Im, Jooyeon Jamie ;
Lee, Sang Hoon ;
Chung, Yong-An .
FRONTIERS IN PSYCHIATRY, 2021, 11
[7]   Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex [J].
Lichenstein, Sarah D. ;
Verstynen, Timothy ;
Forbes, Erika E. .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2016, 70 :271-287
[8]   Post-acute COVID-19 syndrome [J].
Nalbandian, Ani ;
Sehgal, Kartik ;
Gupta, Aakriti ;
Madhavan, Mahesh V. ;
McGroder, Claire ;
Stevens, Jacob S. ;
Cook, Joshua R. ;
Nordvig, Anna S. ;
Shalev, Daniel ;
Sehrawat, Tejasav S. ;
Ahluwalia, Neha ;
Bikdeli, Behnood ;
Dietz, Donald ;
Der-Nigoghossian, Caroline ;
Liyanage-Don, Nadia ;
Rosner, Gregg F. ;
Bernstein, Elana J. ;
Mohan, Sumit ;
Beckley, Akinpelumi A. ;
Seres, David S. ;
Choueiri, Toni K. ;
Uriel, Nir ;
Ausiello, John C. ;
Accili, Domenico ;
Freedberg, Daniel E. ;
Baldwin, Matthew ;
Schwartz, Allan ;
Brodie, Daniel ;
Garcia, Christine Kim ;
Elkind, Mitchell S. V. ;
Connors, Jean M. ;
Bilezikian, John P. ;
Landry, Donald W. ;
Wan, Elaine Y. .
NATURE MEDICINE, 2021, 27 (04) :601-615
[9]   The cingulate cortex and limbic systems for emotion, action, and memory [J].
Rolls, Edmund T. .
BRAIN STRUCTURE & FUNCTION, 2019, 224 (09) :3001-3018
[10]   Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies [J].
Su, Liang ;
Cai, Yiyun ;
Xu, Yifeng ;
Dutt, Anirban ;
Shi, Shenxun ;
Bramon, Elvira .
BMC PSYCHIATRY, 2014, 14