Thyroid cancer in adolescents and young adults

被引:53
作者
Massimino, Maura [1 ]
Evans, Douglas B. [2 ]
Podda, Marta [1 ]
Spinelli, Claudio [3 ]
Collini, Paola [4 ]
Pizzi, Natalia [5 ]
Bleyer, Archie [6 ]
机构
[1] Fdn IRCCS Ist Nazl Tumori, Pediat Unit, Via Venezian 1, I-20133 Milan, Italy
[2] Med Coll Wisconsin, Dept Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA
[3] Univ Pisa, Dept Surg, Div Pediat & Adolescent Surg, Pisa, Italy
[4] Fdn IRCCS Ist Nazl Tumori, Dept Diagnost Pathol & Lab Med, Milan, Italy
[5] Fdn IRCCS Ist Nazl Tumori, Dept Otorhinol & Maxillofacial Surg, Milan, Italy
[6] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA
关键词
adolescents; overdiagnosis; thyroid cancer; young adults; MULTIPLE ENDOCRINE NEOPLASIA; TERM-FOLLOW-UP; NEEDLE-ASPIRATION BIOPSY; SURGICAL-MANAGEMENT; THERAPEUTIC RADIATION; RADIOACTIVE IODINE; CHERNOBYL ACCIDENT; RET PROTOONCOGENE; NUCLEAR FEATURES; NODE DISSECTION;
D O I
10.1002/pbc.27025
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In adolescents and young adults, thyroid cancer accounts for 13% of all invasive neoplasms, being three times more frequent in females, but overdiagnosis and overtreatment are common. There are two therapeutic approaches, one radical and no longer preferred in all instances, and the other conservative. Permanent complications of surgery and metabolic irradiation can affect quality of life and carry an economic burden. The overall survival rate approaches 100% for patients with differentiated thyroid cancer regardless of the extent of treatment. Medullary thyroid carcinoma is a very different entity, occurring most frequently in the context of hereditary tumor susceptibility syndromes.
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页数:9
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