Imaging of cancer invasion and metastasis using green fluorescent protein

被引：49

作者：

Condeelis, JS ^{[1
]}

Wyckoff, J ^{[1
]}

Segall, JE ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Anat & Struct Biol, Bronx, NY 10461 USA

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

GFP; green fluorescent protein; cancer; metastasis; motility; intravasation; extravasation; in vivo videomicroscopy; confocal microscopy;

D O I：

10.1016/S0959-8049(00)00155-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of green fluorescent protein to fluorescently tag tumour cells has allowed investigators to open the "black box" of metastasis in order to visualise the behaviour of tumour cells in living tissues. Analysis of cells leaving the primary tumour indicates that highly metastatic cells are able to polarise more effectively towards blood vessels while poorly metastatic cells fragment more often when interacting with blood. In addition, there appear to be greater numbers of host immune system cells interacting with metastatic tumours. After arresting in target organs such as the lungs or liver, most tumour cells become dormant or apoptose. A small fraction of the arrested cells form metastases. In some target organs, migration of tumour cells may enhance the ability to form metastases. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1671 / 1680

页数：10

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