Identifying Sparse Connectivity Patterns in the brain using resting-state fMRI

被引:75
作者
Eavani, Harini [1 ]
Satterthwaite, Theodore D. [1 ,2 ]
Filipovych, Roman [1 ]
Gur, Raquel E. [2 ]
Gur, Ruben C. [2 ]
Davatzikos, Christos [1 ]
机构
[1] Univ Penn, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Psychiat, Brain Behav Lab, Philadelphia, PA 19104 USA
关键词
Resting state fMRI; Functional connectivity; Sparsity; FUNCTIONAL CONNECTIVITY; DEFAULT-MODE; GLOBAL SIGNAL; NETWORKS; MOTION; ROBUST; FLUCTUATIONS; REGISTRATION; ALGORITHMS; REGRESSION;
D O I
10.1016/j.neuroimage.2014.09.058
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The human brain processes information via multiple distributed networks. An accurate model of the brain's functional connectome is critical for understanding both normal brain function as well as the dysfunction present in neuropsychiatric illnesses. Current methodologies that attempt to discover the organization of the functional connectome typically assume spatial or temporal separation of the underlying networks. This assumption deviates from an intuitive understanding of brain function, which is that of multiple, inter-dependent spatially overlapping brain networks that efficiently integrate information pertinent to diverse brain functions. It is now increasingly evident that neural systems use parsimonious formations and functional representations to efficiently process information while minimizing redundancy. Hence we exploit recent advances in the mathematics of sparse modeling to develop a methodological framework aiming to understand complex resting-state fMRI connectivity data. By favoring networks that explain the data via a relatively small number of participating brain regions, we obtain a parsimonious representation of brain function in terms of multiple "Sparse Connectivity Patterns" (SCPs), such that differential presence of these SCPs explains inter-subject variability. In this manner the sparsity-based framework can effectively capture the heterogeneity of functional activity patterns across individuals while potentially highlighting multiple sub-populations within the data that display similar patterns. Our results from simulated as well as real resting state fMRI data show that SCPs are accurate and reproducible between sub-samples as well as across datasets. These findings substantiate existing knowledge of intrinsic functional connectivity and provide novel insights into the functional organization of the human brain. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:286 / 299
页数:14
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