PI3K/AKT/mTOR pathway inhibitors in triple-negative breast cancer: a review on drug discovery and future challenges

被引：201

作者：

Khan, Mohammad A. ^{[1
]}

Jain, Vineet K. ^{[3
]}

Rizwanullah, Md. ^{[4
]}

Ahmad, Javed ^{[2
]}

Jain, Keerti ^{[3
]}

机构：

[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacol, New Delhi 110062, India

[2] Najran Univ, Coll Pharm, Dept Pharmaceut, Najran, Saudi Arabia

[3] DPSRU, New Delhi 110017, India

[4] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 11期

关键词：

THERAPEUTIC TARGETS; EXPRESSION; DELIVERY; CELLS; PROGRESSION; METASTASIS; THERAPIES; TRIALS; PD-L1;

D O I：

10.1016/j.drudis.2019.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Triple-negative breast cancer (TNBC) is a highly malignant subtype of breast cancer associated with poor prognosis. Although conventional chemotherapy regimens have shown some effectiveness in early TNBC cases, the outcome in advanced stages is poor. The PI3K/AKT/mTOR pathway is one of the important and active pathways involved in chemoresistance and survival of TNBC. This pathway is speculated to play an important part in malignant transformation and has been considered as a potential molecular target for the design of therapeutic agents to treat TNBC. This review discusses the potentials and drug discovery perspectives of PI3K/AKT/mTOR as a therapeutic target for effective management of TNBC with anticipated challenges.

引用

页码：2181 / 2191

页数：11

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