Post-vaccination serologic testing of infants born to hepatitis B surface antigen positive mothers in 4 provinces of China

被引：40

作者：

Wang, Fuzhen ^{[1
]}

Zhang, Guomin ^{[1
]}

Zheng, Hui ^{[1
]}

Miao, Ning ^{[1
]}

Shen, Liping ^{[2
]}

Wang, Feng ^{[2
]}

Dong, Pumei ^{[3
]}

Du, Fei ^{[4
]}

Chen, Chao ^{[5
]}

Zhang, Xiaoshu ^{[6
]}

Cui, Fuqiang ^{[7
]}

机构：

[1] Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China

[2] Chinese Ctr Dis Control & Prevent, Inst Virol Dis Control, Beijing, Peoples R China

[3] Henan Prov Ctr Dis Control & Prevent, Zhengzhou, Henan, Peoples R China

[4] Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China

[5] Jilin Prov Ctr Dis Control & Prevent, Changchun, Jilin, Peoples R China

[6] Gansu Prov Ctr Dis Control & Prevent, Lanzhou, Gansu, Peoples R China

[7] Peking Univ, Sch Publ Hlth, Beijing, Peoples R China

来源：

VACCINE | 2017年 / 35卷 / 33期

关键词：

Hepatitis B; Mother-to-child transmission; Vaccine; Immunization; TO-CHILD TRANSMISSION; PREVENTION; VACCINE; PROTECTION; PROGRAM; VIRUS; RISK;

D O I：

10.1016/j.vaccine.2017.06.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To evaluate prenatal maternal hepatitis B virus (HBV) screening and post-vaccination hepatitis B surface antigen (FIBsAg) and antibody to hepatitis B surface antigen (anti-HBs) status and titers of babies born to HBsAg positive mothers, and to provide evidence for development of standard postvaccination serologic testing (PVST) strategies for babies born to HBsAg positive mothers in China. Methods: In 2014, we conducted a baseline survey of HBV mother to child transmission (MTCT) interruption strategy implementation and PVST for babies born to HBsAg positive mothers after received 3 doses of hepatitis B vaccine (HepB) in 8 counties in 4 Provinces. Bivariate analysis and multivariable analyses modeled statistically significant predictor variables associated with infant HBsAg, anti-HBs positive, anti-HBs titer. Results: Among the 1563 infants born to HBsAg positive mothers, 1025 (65.6%) maternal-infant pairs were enrolled in PVST after receiving 3 doses of HepB. 38 infants tested HBsAg positive for an HBsAg positive rate of 3.7%. Maternal hepatitis B e antigen (HBeAg) status and age of infant were significantly associated with infant HBsAg positivity. A total of 932 infants were anti-HBs positive when tested at 724 months of age, yielding an anti-HBs positivity rate of 90.9%. Maternal HBeAg status was the factor associated with infant anti-HBs status. Amount of antigen of HepB and infant's age were most associated with anti-HBs titers. PVST performed 1-2 months after the 3rd dose of HepB was associated with the highest anti-HBs level and the anti-HBs Geometric Mean Concentration (GMC) decreased as the PVST intervals prolonged. Conclusions: In China, perinatal HBV transmission is approaching the theoretical minimum possible with the current strategy of HepB coupled with HBIG administration for HBV-exposed newborns. PVST of infants born to an HBsAg positive mother is an essential strategy to ensure full protection for vaccine non-responders and appropriate medical care for those infected. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4229 / 4235

页数：7

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