Cryptococcal antigen detection in broncho-alveolar lavage fluid

被引：8
|
作者：
Senghor, Y. [1 ]
Guitard, J. [1 ,2 ]
Angoulvant, A. [3 ,4 ]
Hennequin, C. [1 ,2 ]
机构：
[1] Hop St Antoine, AP HP, Serv Parasitol Mycol, F-75012 Paris, France
[2] UPMC Univ Paris 06, Sorbonne Univ, INSERM, UMR S 1135,CNRS,ERL 8255,Ctr Immunol & Malad Infe, F-75013 Paris, France
[3] Hop Bicetre, AP HP, Unite Parasitol Mycol, F-94270 Le Kremlin Bicetre, France
[4] Univ Paris 11, GQE Le Moulon, INRA, CNRS,AgroParisTech, F-91400 Orsay, France
来源：
MEDICAL MYCOLOGY | 2018年 / 56卷 / 06期
关键词：
Cryptococcosis; pneumonia; diagnosis; antigen; UTILITY; NEOFORMANS; AIDS;
D O I：
10.1093/mmy/myx092
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Cryptococcal antigen (CryAg) testing in serum and CSF is a clue diagnostic tool for cryptococcosis. In this study, we reviewed the performances of the CryAg detection (Premier EIA, Meridian) routinely performed in broncho-alveolar lavage fluid (BALF) during a 7year period (2007-2013). CryAg was detected in 12 cases among 4650 BALF analyzed, while positive culture from BALF was detected in nine cases. We found sensitivity, specificity, positive and negative predictive values at 0.44-0.80 (according to the radio-clinical form), 0.99, 0.36, and 0.99, respectively. These results do not support the routine use of the test in BALE.
引用
收藏
页码：774 / 777
页数：4
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