Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study

被引：225

作者：

Reininghaus, Ulrich ^{[1
,2
]}

Kempton, Matthew J. ^{[3
]}

Valmaggia, Lucia ^{[4
]}

Craig, Tom K. J. ^{[1
]}

Garety, Philippa ^{[4
]}

Onyejiaka, Adanna ^{[4
]}

Gayer-Anderson, Charlotte ^{[1
]}

So, Suzanne H. ^{[5
]}

Hubbard, Kathryn ^{[1
]}

Beards, Stephanie ^{[1
]}

Dazzan, Paola ^{[3
,6
,7
]}

Pariante, Carmine ^{[6
,7
,8
]}

Mondelli, Valeria ^{[6
,7
,8
]}

Fisher, Helen L. ^{[9
]}

Mills, John G. ^{[3
]}

Viechtbauer, Wolfgang ^{[2
]}

McGuire, Philip ^{[3
,6
,7
]}

van Os, Jim ^{[2
]}

Murray, Robin M. ^{[3
,6
,7
]}

Wykes, Til ^{[4
]}

Myin-Germeys, Inez ^{[2
,10
]}

Morgan, Craig ^{[1
,6
,7
]}

机构：

[1] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Epidemiol & Publ Hlth, Hlth Serv & Populat Res Dept, De Crespigny Pk, London SE5 8AF, England

[2] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, NL-6200 MD Maastricht, Netherlands

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychosis Studies Dept, London SE5 8AF, England

[4] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychol Dept, London SE5 8AF, England

[5] Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China

[6] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res, Mental Hlth Biomed Res Ctr, London, England

[7] Kings Coll London, London SE5 8AF, England

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London SE5 8AF, England

[9] Kings Coll London, Inst Psychiat Psychol & Neurosci, MRC, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England

[10] Katholieke Univ Leuven, Ctr Contextual Psychiat, Dept Neurosci, Leuven, Belgium

来源：

SCHIZOPHRENIA BULLETIN | 2016年 / 42卷 / 03期

基金：

英国惠康基金;

关键词：

stress sensitivity; aberrant salience; threat anticipation; ecological momentary assessment; prodrome; first-episode psychosis; SCHIZOPHRENIA-SPECTRUM DISORDERS; DAILY-LIFE STRESS; HIGH-RISK STATE; PERSECUTORY DELUSIONS; SOCIAL DISADVANTAGE; GENERAL-POPULATION; ENVIRONMENTAL RISK; LINKING BIOLOGY; INDIVIDUALS; REACTIVITY;

D O I：

10.1093/schbul/sbv190

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

While contemporary models of psychosis have proposed a number of putative psychological mechanisms, how these impact on individuals to increase intensity of psychotic experiences in real life, outside the research laboratory, remains unclear. We aimed to investigate whether elevated stress sensitivity, experiences of aberrant novelty and salience, and enhanced anticipation of threat contribute to the development of psychotic experiences in daily life. We used the experience sampling method (ESM) to assess stress, negative affect, aberrant salience, threat anticipation, and psychotic experiences in 51 individuals with first-episode psychosis (FEP), 46 individuals with an at-risk mental state (ARMS) for psychosis, and 53 controls with no personal or family history of psychosis. Linear mixed models were used to account for the multilevel structure of ESM data. In all 3 groups, elevated stress sensitivity, aberrant salience, and enhanced threat anticipation were associated with an increased intensity of psychotic experiences. However, elevated sensitivity to minor stressful events (chi(2) = 6.3, P = 0.044), activities (chi(2) = 6.7, P = 0.036), and areas (chi(2) = 9.4, P = 0.009) and enhanced threat anticipation (chi(2) = 9.3, P = 0.009) were associated with more intense psychotic experiences in FEP individuals than controls. Sensitivity to outsider status (chi(2) = 5.7, P = 0.058) and aberrantly salient experiences (chi(2) = 12.3, P = 0.002) were more strongly associated with psychotic experiences in ARMS individuals than controls. Our findings suggest that stress sensitivity, aberrant salience, and threat anticipation are important psychological processes in the development of psychotic experiences in daily life in the early stages of the disorder.

引用

页码：712 / 722

页数：11

共 86 条

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