Tumor-Infiltrating Leukocyte Phenotypes Distinguish Outcomes in Related Patients With Pancreatic Adenocarcinoma

被引：2

作者：

Link, Jason M. ^{[1
,2
]}

Liudahl, Shannon M. ^{[3
]}

Betts, Courtney B. ^{[3
]}

Sivagnanam, Shamilene ^{[4
]}

Leis, Kenna R. ^{[4
]}

McDonnell, Mary ^{[2
,5
,6
]}

Pelz, Carl R. ^{[2
,4
]}

Johnson, Brett ^{[5
,6
]}

Hamman, Kelly J. ^{[1
]}

Keith, Dove ^{[2
]}

Sampson, Jone E. ^{[1
]}

Morgan, Terry K. ^{[3
,7
]}

Lopez, Charles D. ^{[2
,8
,9
]}

Coussens, Lisa M. ^{[2
,3
,9
]}

Sears, Rosalie C. ^{[1
,2
,9
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Brenden Colson Ctr Pancreat Care, 2730 S Moody Ave, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97201 USA

[4] Oregon Hlth & Sci Univ, Computat Biol, Portland, OR 97201 USA

[5] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97201 USA

[6] Oregon Hlth & Sci Univ, OHSU Ctr Spatial Syst Biomed, Portland, OR 97201 USA

[7] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA

[8] Dept Hematol & Oncol, Portland, OR USA

[9] Knight Canc Inst, Portland, OR USA

来源：

JCO PRECISION ONCOLOGY | 2021年 / 5卷

关键词：

DUCTAL ADENOCARCINOMA; PULMONARY METASTASES; TRYPSINOGEN PRSS1; GENE-MUTATIONS; CANCER; SUBTYPES; HETEROGENEITY; SURVIVAL; RISK; IMMUNOTHERAPY;

D O I：

10.1200/PO.20.00287

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：344 / 356

页数：13

共 65 条

[1] Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma [J].

Aguirre, Andrew J. ;

Hruban, Ralph H. ;

Raphael, Benjamin J. .

CANCER CELL, 2017, 32 (02) :185-+

[2]

[Anonymous], 2018, Cancer Facts and Figures 2018

[3] Genomic analyses identify molecular subtypes of pancreatic cancer [J].

Bailey, Peter ;

Chang, David K. ;

Nones, Katia ;

Johns, Amber L. ;

Patch, Ann-Marie ;

Gingras, Marie-Claude ;

Miller, David K. ;

Christ, Angelika N. ;

Bruxner, Tim J. C. ;

Quinn, Michael C. ;

Nourse, Craig ;

Murtaugh, L. Charles ;

Harliwong, Ivon ;

Idrisoglu, Senel ;

Manning, Suzanne ;

Nourbakhsh, Ehsan ;

Wani, Shivangi ;

Fink, Lynn ;

Holmes, Oliver ;

Chin, Vencssa ;

Anderson, Matthew J. ;

Kazakoff, Stephen ;

Leonard, Conrad ;

Newell, Felicity ;

Waddell, Nick ;

Wood, Scott ;

Xu, Qinying ;

Wilson, Peter J. ;

Cloonan, Nicole ;

Kassahn, Karin S. ;

Taylor, Darrin ;

Quek, Kelly ;

Robertson, Alan ;

Pantano, Lorena ;

Mincarelli, Laura ;

Sanchez, Luis N. ;

Evers, Lisa ;

Wu, Jianmin ;

Pinese, Mark ;

Cowley, Mark J. ;

Jones, Marc D. ;

Colvin, Emily K. ;

Nagrial, Adnan M. ;

Humphrey, Emily S. ;

Chantrill, Lorraine A. ;

Mawson, Amanda ;

Humphris, Jeremy ;

Chou, Angela ;

Pajic, Marina ;

Scarlett, Christopher J. .

NATURE, 2016, 531 (7592) :47-+

[4] Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer [J].

Balachandran, Vinod P. ;

Luksza, Marta ;

Zhao, Julia N. ;

Makarov, Vladimir ;

Moral, John Alec ;

Remark, Romain ;

Herbst, Brian ;

Askan, Gokce ;

Bhanot, Umesh ;

Senbabaoglu, Yasin ;

Wells, Daniel K. ;

Cary, Charles Ian Ormsby ;

Grbovic-Huezo, Olivera ;

Attiyeh, Marc ;

Medina, Benjamin ;

Zhang, Jennifer ;

Loo, Jennifer ;

Saglimbeni, Joseph ;

Abu-Akeel, Mohsen ;

Zappasodi, Roberta ;

Riaz, Nadeem ;

Smoragiewicz, Martin ;

Kelley, Z. Larkin ;

Basturk, Olca ;

Goenen, Mithat ;

Levine, Arnold J. ;

Allen, Peter J. ;

Fearon, Douglas T. ;

Merad, Miriam ;

Gnjatic, Sacha ;

Iacobuzio-Donahue, Christine A. ;

Wolchok, Jedd D. ;

DeMatteo, Ronald P. ;

Chan, Timothy A. ;

Greenbaum, Benjamin D. ;

Merghoub, Taha ;

Leach, Steven D. .

NATURE, 2017, 551 (7681) :512-+

[5] Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer [J].

Balli, David ;

Rech, Andrew J. ;

Stanger, Ben Z. ;

Vonderheide, Robert H. .

CLINICAL CANCER RESEARCH, 2017, 23 (12) :3129-3138

[6] Prevailing over T cell exhaustion: New developments in the immunotherapy of pancreatic cancer [J].

Bauer, Christian ;

Kuehnemuth, Benjamin ;

Duewell, Peter ;

Ormanns, Steffen ;

Gress, Thomas ;

Schnurr, Max .

CANCER LETTERS, 2016, 381 (01) :259-268

[7] SMAD4 Gene Mutations Are Associated with Poor Prognosis in Pancreatic Cancer [J].

Blackford, Amanda ;

Serrano, Oscar K. ;

Wolfgang, Christopher L. ;

Parmigiani, Giovanni ;

Jones, Sian ;

Zhang, Xiaosong ;

Parsons, D. Williams ;

Lin, Jimmy Cheng-Ho ;

Leary, Rebecca J. ;

Eshleman, James R. ;

Goggins, Michael ;

Jaffee, Elizabeth M. ;

Iacobuzio-Donahue, Christine A. ;

Maitra, Anirban ;

Cameron, John L. ;

Olino, Kelly ;

Schulick, Richard ;

Winter, Jordan ;

Herman, Joseph M. ;

Laheru, Daniel ;

Klein, Alison P. ;

Vogelstein, Bert ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Hruban, Ralph H. .

CLINICAL CANCER RESEARCH, 2009, 15 (14) :4674-4679

[8] CellProfiler: image analysis software for identifying and quantifying cell phenotypes [J].

Carpenter, Anne E. ;

Jones, Thouis Ray ;

Lamprecht, Michael R. ;

Clarke, Colin ;

Kang, In Han ;

Friman, Ola ;

Guertin, David A. ;

Chang, Joo Han ;

Lindquist, Robert A. ;

Moffat, Jason ;

Golland, Polina ;

Sabatini, David M. .

GENOME BIOLOGY, 2006, 7 (10)

[9] Validation of Biomarkers That Complement CA19.9 in Detecting Early Pancreatic Cancer [J].

Chan, Alison ;

Prassas, Ioannis ;

Dimitromanolakis, Apostolos ;

Brand, Randall E. ;

Serra, Stefano ;

Diamandis, Eleftherios P. ;

Blasutig, Ivan M. .

CLINICAL CANCER RESEARCH, 2014, 20 (22) :5787-5795

[10] Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution [J].

Chan-Seng-Yue, Michelle ;

Kim, Jaeseung C. ;

Wilson, Gavin W. ;

Ng, Karen ;

Figueroa, Eugenia Flores ;

O'Kane, Grainne M. ;

Connor, Ashton A. ;

Denroche, Robert E. ;

Grant, Robert C. ;

McLeod, Jessica ;

Wilson, Julie M. ;

Jang, Gun Ho ;

Zhang, Amy ;

Liang, Sheng-Ben ;

Borgida, Ayelet ;

Chadwick, Dianne ;

Kalimuthu, Sangeetha ;

Lungu, Ilinca ;

Bartlett, John M. S. ;

Krzyzanowski, Paul M. ;

Sandhu, Vandana ;

Tiriac, Herve ;

Froeling, Fieke E. M. ;

Karasinska, Joanna M. ;

Topham, James T. ;

Renouf, Daniel J. ;

Schaeffer, David F. ;

Jones, Steven J. M. ;

Marra, Marco A. ;

Laskin, Janessa ;

Chetty, Runjan ;

Stein, Lincoln D. ;

Zogopoulos, George ;

Haibe-Kains, Benjamin ;

Campbell, Peter J. ;

Tuveson, David A. ;

Knox, Jennifer J. ;

Fischer, Sandra E. ;

Gallinger, Steven ;

Notta, Faiyaz .

NATURE GENETICS, 2020, 52 (02) :231-+

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