Genetic Variants of CD209 Associated with Kawasaki Disease Susceptibility

被引:11
作者
Kuo, Ho-Chang [1 ,2 ,3 ]
Huang, Ying-Hsien [1 ,2 ,3 ]
Chien, Shu-Chen [4 ,6 ]
Yu, Hong-Ren [1 ,2 ,3 ]
Hsieh, Kai-Sheng [1 ,2 ,3 ]
Hsu, Yu-Wen [4 ,5 ]
Chang, Wei-Chiao [4 ,5 ,7 ,8 ]
机构
[1] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung, Taiwan
[2] Kaohsiung Chang Gung Mem Hosp, Kawasaki Dis Ctr, Kaohsiung, Taiwan
[3] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan
[4] Taipei Med Univ, Sch Pharm, Dept Clin Pharm, Taipei, Taiwan
[5] Taipei Med Univ, Sch Pharm, Master Program Clin Pharmacogenom & Pharmacoprote, Taipei, Taiwan
[6] Taipei Med Univ Hosp, Dept Pharm, Taipei, Taiwan
[7] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Ctr Canc, Kaohsiung, Taiwan
[8] Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan
来源
PLOS ONE | 2014年 / 9卷 / 08期
关键词
GENOME-WIDE ASSOCIATION; IMMUNOGLOBULIN TREATMENT FAILURE; DC-SIGN; EPIDEMIOLOGIC FEATURES; INFECTION; VIRUS; TUBERCULOSIS; POLYMORPHISM; DIAGNOSIS; IMMUNITY;
D O I
10.1371/journal.pone.0105236
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Kawasaki disease (KD) is a systemic vasculitis with unknown etiology mainly affecting children in Asian countries. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) in humans was showed to trigger an anti-inflammatory cascade and associated with KD susceptibility. This study was conducted to investigate the association between genetic polymorphisms of CD209 and the risk KD. Methods: A total of 948 subjects (381 KD and 567 controls) were recruited. Nine tagging SNPs (rs8112310, rs4804800, rs11465421, rs1544766, rs4804801, rs2287886, rs735239, rs735240, rs4804804) were selected for TaqMan allelic discrimination assay. Clinical phenotypes, coronary artery lesions (CAL) and intravenous immunoglobulin (IVIG) treatment outcomes were collected for analysis. Results: Significant associations were found between CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD. Haplotype analysis for CD209 polymorphisms showed that A/A/G haplotype (P = 0.0002, OR = 1.61) and G/A/G haplotype (P = 0.0365, OR = 1.52) had higher risk of KD as compared with G/G/A haplotype in rs2287886/rs735239/rs735240 pairwise allele analysis. There were no significant association in KD with regards to CAL formation and IVIG treatment responses. Conclusion: CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness.
引用
收藏
页数:8
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