Messenger proteins: homeoproteins, TAT and others

被引:262
作者
Prochiantz, A [1 ]
机构
[1] Ecole Normale Super, CNRS, UMR 8542, F-75230 Paris 5, France
关键词
D O I
10.1016/S0955-0674(00)00108-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Some proteins are internalized by live cells by a process that does not involve classical endocytosis and thus gain direct access to the cytoplasm and nucleus. These same proteins are often secreted, despite the absence of a signal peptide. Recent studies of this unexpected mode of intercellular signaling have opened the way for biotechnological developments.
引用
收藏
页码:400 / 406
页数:7
相关论文
共 48 条
[21]   ANTENNAPEDIA HOMEOBOX PEPTIDE REGULATES NEURAL MORPHOGENESIS [J].
JOLIOT, A ;
PERNELLE, C ;
DEAGOSTINIBAZIN, H ;
PROCHIANTZ, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) :1864-1868
[22]   Engrailed, Wnt and Pax genes regulate midbrain hindbrain development [J].
Joyner, AL .
TRENDS IN GENETICS, 1996, 12 (01) :15-20
[23]   Import(ance) of growth factors in(to) the nucleus [J].
Keresztes, M ;
Boonstra, J .
JOURNAL OF CELL BIOLOGY, 1999, 145 (03) :421-424
[24]   HOX GENES IN VERTEBRATE DEVELOPMENT [J].
KRUMLAUF, R .
CELL, 1994, 78 (02) :191-201
[25]   ATP treatment of human monocytes promotes caspase-1 maturation and externalization [J].
Laliberte, RE ;
Eggler, J ;
Gabel, CA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (52) :36944-36951
[26]   Probing plant cell structure and function with viral movement proteins [J].
Lazarowitz, SG .
CURRENT OPINION IN PLANT BIOLOGY, 1999, 2 (04) :332-338
[27]   NEUROTROPHIC ACTIVITY OF THE ANTENNAPEDIA HOMEODOMAIN DEPENDS ON ITS SPECIFIC DNA-BINDING PROPERTIES [J].
LEROUX, I ;
JOLIOT, AH ;
BLOCHGALLEGO, E ;
PROCHIANTZ, A ;
VOLOVITCH, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (19) :9120-9124
[28]  
LINGREN M, 2000, TRENDS PHARMACOL SCI, V21, P99
[29]   Identification of caveolin-1 in lipoprotein particles secreted by exocrine cells [J].
Liu, PS ;
Li, WP ;
Machleidt, T ;
Anderson, RGW .
NATURE CELL BIOLOGY, 1999, 1 (06) :369-375
[30]  
Loomis CA, 1998, DEVELOPMENT, V125, P1137