Treatment strategies for locally advanced non-small cell lung cancer in elderly patients: Translating scientific evidence into clinical practice

被引：13

作者：

Bonanno, Laura ^{[1
]}

Attili, Ilaria ^{[2
]}

Pavan, Alberto ^{[1
]}

Sepulcri, Matteo ^{[3
]}

Pasello, Giulia ^{[1
,4
]}

Rea, Federico ^{[5
]}

Guarneri, Valentina ^{[1
,4
]}

Conte, PierFranco ^{[1
,4
]}

机构：

[1] IRCCS, Med Oncol 2, Ist Oncol Veneto, Via Gattamelata 64, I-35128 Padua, Italy

[2] IRCSS, Div Thorac Oncol, European Inst Oncol, Milan, Italy

[3] IRCCS, Radiotherapy, Ist Oncol Veneto, Padua, Italy

[4] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

[5] Univ Padua, Dept Cardiothorac Surg & Vasc Sci, Thorac Surg, Padua, Italy

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2021年 / 163卷

关键词：

Stage III lung cancer; Elderly; Radiotherapy; Chemotherapy; Immunotherapy; Concurrent treatment; Sequential treatment; Comorbidities; COMPREHENSIVE GERIATRIC ASSESSMENT; LOW-DOSE CARBOPLATIN; PHASE-III TRIAL; INDUCTION CHEMOTHERAPY; RADIATION PNEUMONITIS; THORACIC RADIOTHERAPY; PERFORMANCE STATUS; RANDOMIZED-TRIAL; ITALIAN COHORT; OLDER PATIENTS;

D O I：

10.1016/j.critrevonc.2021.103378

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Treatment of locally advanced NSCLC (LA-NSCLC) is focused on multimodal strategy, including chemotherapy and radiotherapy (in combination or as alternative treatments), followed by surgery in selected cases. Recently, durvalumab consolidation after definitive chemo-radiation has shown a meaningful overall survival benefit. However, it is important to note that elderly patients represent a high proportion of NSCLC population and frailty and comorbidities can significantly limit treatment options. Indeed, elderly patients are under-represented in clinical trials and data to drive treatment selection in this category of patients are scanty. Available data, main issues and controversies on multimodal treatment in elderly LA-NSCLC patients will be reviewed in this paper.

引用

页数：10

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