CORONARY HEART DISEASE DETECTION USING NONLINEAR FEATURES AND ONLINE SEQUENTIAL EXTREME LEARNING MACHINE

In this paper, we propose an automated approach that combines the generalized discriminant analysis (GDA) as feature reduction scheme with radial basis function (RBF) kernel and the online sequential extreme learning machine (OSELM) having Sigmoid, Hardlim, RBF and Sine activation function as binary classifier for detection of congestive heart failure (CHF) and coronary artery disease (CAD). For this analysis, 13 nonlinear features as Correlation Dimension (CD), Detrended Fluctuation Analysis (DFA) as DFA-alpha 1 and DFA-alpha 2, Bubble Entropy (BBEn), Sample Entropy (SampEn), Dispersion Entropy (DISEn), Lempel-Ziv Complexity (LZ), Sinai Entropy (SIEn), Improved Multiscale Permutation Entropy (IMPE), Hurst Exponent (HE), Permutation Entropy (PE), Approximate Entropy (ApEn) and Standard Deviation (SD1/SD2) were extracted from Heart Rate Variability (HRV) signals. For validation of proposed method, HRV data were obtained from standard database of normal sinus rhythm (NSR), CHF and CAD subjects. Numerical experiments were done on the combination of database sets such as NSR-CAD, CHF-CAD and NSR-CHF subjects. The simulation results show a clear difference in combination of database sets by using GDA having RBF, Gaussian kernel function and OSELM binary classifier having Sigmoid, RBF and Sine activation function and achieved an accuracy of 98.17% for NSR-CAD, 100% for NSR-CHF and CAD-CHF subjects.