Current immuno-oncology in head and neck cancer

For many years surgery, radiotherapy and chemotherapy dominated the treatment in head and neck malignancies. Refinements of the particular techniques, either in surgery or in radiooncology, brought some progress. However, clinical outcome data are still not satisfying and side effects and long term toxicities are significant. Apart of the improvement of overall results, the reduction of side effects stays a main goal in this field. Targeted therapies as well as immune modulating therapies represent a new generation in the treatment of cancer. The development of new and highly effective substances makes rapid progress and immunotherapy has become a standard in the treatment of recurrent head and neck cancer. The following chapter will give you an actual review about the status quo of immunotherapy in head neck malignancies.