Mutated tau, amyloid and neuroinflammation in Alzheimer disease-A brief review

被引：36

作者：

Hung, A. S. M. ^{[1
,2
]}

Liang, Y. ^{[3
]}

Chow, Tony C. H. ^{[1
,2
]}

Tang, H. C. ^{[1
,2
]}

Wu, Sharon L. Y. ^{[1
,2
]}

Wai, M. S. M. ^{[1
,2
]}

Yew, D. T. ^{[1
,2
]}

机构：

[1] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Sch Chinese Med, Shatin, Hong Kong, Peoples R China

[3] Taizhou Univ, Sch Med, Taizhou, Zhejiang, Peoples R China

来源：

PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY | 2016年 / 51卷 / 01期

关键词：

Mutated tau; Amyloid; CD4; TNF alpha; Microglia; NEUROFIBRILLARY TANGLES; HYPERPHOSPHORYLATED TAU; T-CELLS; SYNAPTIC PLASTICITY; CEREBROSPINAL-FLUID; PREFRONTAL CORTEX; DIFFERENT REGIONS; POSITIVE CELLS; IN-VIVO; BRAIN;

D O I：

10.1016/j.proghi.2016.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review discussed the importance of mutated tau, amyloid and neuroinflammatory factors and microglia in Alzheimer disease. In particular tau, CD4 and TNF alpha were included in the review and the colocalizations of these factors were highlighted. It is important to realize the Alzheimer disease may result from the interactions of these factors. Some of these factors may coexist at the same region and at the same time e.g. mutated tau and amyloid in plaques. A summary scheme of etiology leading to the disease was included. (C) 2016 Elsevier GmbH. All rights reserved.

引用

页码：1 / 8

页数：8

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