Intraretinal Hyperreflective Foci in Acquired Vitelliform Lesions of the Macula: Clinical and Histologic Study

被引：89

作者：

Chen, Kevin C. ^{[1
]}

Jung, Jesse J. ^{[1
,2
,3
,4
]}

Curcio, Christine A. ^{[5
]}

Balaratnasingam, Chandrakumar ^{[3
,4
,6
]}

Gallego-Pinazo, Roberto ^{[7
]}

Dolz-Marco, Rosa ^{[7
]}

Freund, K. Bailey ^{[1
,2
,3
,4
]}

Yannuzzi, Lawrence A. ^{[1
,2
,3
,4
]}

机构：

[1] NYU, Sch Med, Dept Ophthalmol, New York, NY USA

[2] Columbia Univ Coll Phys & Surg, Dept Ophthalmol, Edward S Harkness Eye Inst, New York, NY 10032 USA

[3] Vitreous Retina Macula Consultants New York, 460 Pk Ave,Fifth Floor, New York, NY 10022 USA

[4] Manhattan Eye Ear & Throat Hosp, LuEsther T Mertz Retinal Res Ctr, New York, NY 10021 USA

[5] Univ Alabama Birmingham, Sch Med, Dept Ophthalmol, Birmingham, AL USA

[6] Univ Western Australia, Lions Eye Inst, Dept Physiol & Pharmacol, Perth, WA 6009, Australia

[7] Univ & Polytech Hosp La Fe, Dept Ophthalmol, Valencia, Spain

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 2016年 / 164卷

关键词：

OPTICAL COHERENCE TOMOGRAPHY; RETINAL-PIGMENT EPITHELIUM; DEGENERATION; DYSTROPHY; EYES; DISEASE; CELLS; SIGN; DRY;

D O I：

10.1016/j.ajo.2016.02.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To describe the natural course, visual outcomes, and anatomic changes and provide histologic correlates in eyes with intraretinal hyperreflective foci associated with acquired vitelliform lesions. DESIGN: Retrospective cohort study and imaging histology correlation in a single donor eye. METHODS: PARTICIPANTS: Patients with intraretinal hyperreflective foci and acquired vitelliform lesions from 2 tertiary referral centers were evaluated from January 2002 to January 2014. MAIN OUTCOME MEASURES: The chronology of clinical and imaging features of retinal anatomic changes and the pattern of intraretinal hyperreflective foci migration were documented using spectral-domain optical coherence tomography (OCT). One donor eye with intraretinal hyperreflective foci was identified in a pathology archive by ex vivo OCT and was studied with high resolution light and electron microscopic examination. RESULTS: Intraretinal hyperreflective foci were associated with acquired vitelliform lesions in 25 of 254 eyes (9.8%) with a strong female preponderance (86% of patients). Focal disruptions to the ellipsoid zone and external limiting membrane overlying the acquired vitelliform lesions were observed prior to the occurrence of intraretinal hyperreflective foci in 75% of cases. Histologic evaluation showed that intraretinal hyperreflective foci represent cells of retinal pigment epithelium origin that are similar to those found in the vitelliform lesions themselves and contain lipofuscin granules, melanolipofuscin granules, and melanosomes. The occurrence of intraretinal hyperreflective foci was not a significant determinant of final visual acuity (P = .34), but development of outer retinal atrophy was (P = .003). CONCLUSIONS: Intraretinal hyperreflective foci associated with acquired vitelliform lesions are of retinal pigment epithelium origin, and the natural course and functional changes are described. (C) 2016 by Elsevier Inc. All rights reserved.

引用

页码：89 / 98

页数：10

共 28 条

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