Pathway analysis identified a significant association between cell-cell adherens junctions-related genes and non-syndromic cleft lip/palate in 895 Asian case-parent trios

被引：1

作者：

Li, Mengying ^{[1
,2
]}

Wang, Hong ^{[1
,3
]}

机构：

[1] Peking Univ, Sch Publ Hlth, Dept Biostat, Beijing, Peoples R China

[2] Ningbo Municipal Ctr Dis Control & Prevent, Ningbo, Zhejiang, Peoples R China

[3] Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Biostat, 38 Xueyuan Rd Haidian, Beijing 100191, Peoples R China

来源：

ARCHIVES OF ORAL BIOLOGY | 2022年 / 136卷

基金：

中国国家自然科学基金;

关键词：

Adherens junctions; Genetic association studies; Single nucleotide polymorphism; Cleft lip; Cleft palate; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCUS; OROFACIAL CLEFTS; RARE VARIANTS; ORAL CLEFTS; LIP; PALATE; CDH1; CANCER; RISK;

D O I：

10.1016/j.archoralbio.2022.105384

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objectives: To study the association between the seven cell-cell adherens junctions (AJs)-related genes (CDH1, CTNND1, CTNNA1, ESRP1, ESRP2, PLEKHA5, and PLEKHA7) and non-syndromic cleft lip with or without cleft palate (NSCL/P) in the Asian population.& nbsp;Design: The study included 895 NSCL/P case-parent trios of Asian ethnicity drawn from an international consortium established for a genome-wide association study. We performed association analysis by applying the genotypic transmission disequilibrium test for each of the 144 single nucleotide polymorphisms (SNPs), the versatile gene-based association study for the combined effects of all SNPs, all in or around the seven target genes, and the versatile pathway-based approach for the combined effects of these seven target genes, consecutively.& nbsp;Results: In our analysis, we found neither a significant SNP-based nor gene-based association with NSCL/P for any of the 144 relevant SNPs or the seven target genes. However, novel evidence of a significant association (P = 6.00 x 10(-6)) with NSCL/P was observed in the combined effects of these seven target genes in the versatile pathway-based analysis.& nbsp;Conclusions: Our results were consistent with the findings of previously published human sequencing studies and reinforced the role of these cell-cell AJs-related genes in the pathogenesis of NSCL/P that may be replicated using data from other genome-wide association studies. This pathway approach better reflects our current understanding of the biological mechanisms underlying the aetiology of NSCL/P.

引用

页数：5

共 38 条

[1] A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 [J].

Beaty, Terri H. ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Ruczinski, Ingo ;

Hetmanski, Jacqueline B. ;

Liang, Kung Yee ;

Wu, Tao ;

Murray, Tanda ;

Fallin, M. Daniele ;

Redett, Richard A. ;

Raymond, Gerald ;

Schwender, Holger ;

Jin, Sheng-Chih ;

Cooper, Margaret E. ;

Dunnwald, Martine ;

Mansilla, Maria A. ;

Leslie, Elizabeth ;

Bullard, Stephen ;

Lidral, Andrew C. ;

Moreno, Lina M. ;

Menezes, Renato ;

Vieira, Alexandre R. ;

Petrin, Aline ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jabs, Ethylin W. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Wang, Hong ;

Ye, Xiaoqian ;

Huang, Shangzhi ;

Yeow, Vincent ;

Chong, Samuel S. ;

Jee, Sun Ha ;

Shi, Bing ;

Christensen, Kaare ;

Melbye, Mads ;

Doheny, Kimberly F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Castilla, Eduardo E. ;

Czeizel, Andrew E. ;

Ma, Lian ;

Field, L. Leigh ;

Brody, Lawrence ;

Pangilinan, Faith ;

Mills, James L. ;

Molloy, Anne M. ;

Kirke, Peadar N. .

NATURE GENETICS, 2010, 42 (06) :525-U76

[2] Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 [J].

Birnbaum, Stefanie ;

Ludwig, Kerstin U. ;

Reutter, Heiko ;

Herms, Stefan ;

Steffens, Michael ;

Rubini, Michele ;

Baluardo, Carlotta ;

Ferrian, Melissa ;

de Assis, Nilma Almeida ;

Alblas, Margrieta A. ;

Barth, Sandra ;

Freudenberg, Jan ;

Lauster, Carola ;

Schmidt, Guel ;

Scheer, Martin ;

Braumann, Bert ;

Berge, Stefaan J. ;

Reich, Rudolf H. ;

Schiefke, Franziska ;

Hemprich, Alexander ;

Poetzsch, Simone ;

Steegers-Theunissen, Regine P. ;

Poetzsch, Bernd ;

Moebus, Susanne ;

Horsthemke, Bernhard ;

Kramer, Franz-Josef ;

Wienker, Thomas F. ;

Mossey, Peter A. ;

Propping, Peter ;

Cichon, Sven ;

Hoffmann, Per ;

Knapp, Michael ;

Noethen, Markus M. ;

Mangold, Elisabeth .

NATURE GENETICS, 2009, 41 (04) :473-477

[3] Genome-wide Enrichment of De Novo Coding Mutations in Orofacial Cleft Trios [J].

Bishop, Madison R. ;

Perez, Kimberly K. Diaz ;

Sun, Miranda ;

Ho, Samantha ;

Chopra, Pankaj ;

Mukhopadhyay, Nandita ;

Hetmanski, Jacqueline B. ;

Taub, Margaret A. ;

Moreno-Uribe, Lina M. ;

Valencia-Ramirez, Luz Consuelo ;

Restrepo Muneton, Claudia P. ;

Wehby, George ;

Hecht, Jacqueline T. ;

Deleyiannis, Frederic ;

Weinberg, Seth M. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Brand, Harrison ;

Epstein, Michael P. ;

Ruczinski, Ingo ;

Murray, Jeffrey C. ;

Beaty, Terri H. ;

Feingold, Eleanor ;

Lipinski, Robert J. ;

Cutler, David J. ;

Marazita, Mary L. ;

Leslie, Elizabeth J. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2020, 107 (01) :124-136

[4] Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate [J].

Brito, Luciano Abreu ;

Yamamoto, Guilherme Lopes ;

Melo, Soraia ;

Malcher, Carolina ;

Ferreira, Simone Gomes ;

Figueiredo, Joana ;

Alvizi, Lucas ;

Kobayashi, Gerson Shigeru ;

Naslavsky, Michel Satya ;

Alonso, Nivaldo ;

Felix, Temis Maria ;

Zatz, Mayana ;

Seruca, Raquel ;

Passos-Bueno, Maria Rita .

HUMAN MUTATION, 2015, 36 (11) :1029-1033

[5] Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts [J].

Bureau, Alexandre ;

Parker, Margaret M. ;

Ruczinski, Ingo ;

Taub, Margaret A. ;

Marazita, Mary L. ;

Murray, Jeffrey C. ;

Mangold, Elisabeth ;

Noethen, Markus M. ;

Ludwig, Kirsten U. ;

Hetmanski, Jacqueline B. ;

Bailey-Wilson, Joan E. ;

Cropp, Cheryl D. ;

Li, Qing ;

Szymczak, Silke ;

Albacha-Hejazi, Hasan ;

Alqosayer, Khalid ;

Field, L. Leigh ;

Wu-Chou, Yah-Huei ;

Doheny, Kimberly F. ;

Ling, Hua ;

Scott, Alan F. ;

Beaty, Terri H. .

GENETICS, 2014, 197 (03) :1039-+

[6] Genomic analyses in African populations identify novel risk loci for cleft palate [J].

Butali, Azeez ;

Mossey, Peter A. ;

Adeyemo, Wasiu L. ;

Eshete, Mekonen A. ;

Gowans, Lord J. J. ;

Busch, Tamara D. ;

Jain, Deepti ;

Yu, Wenjie ;

Huan, Liu ;

Laurie, Cecelia A. ;

Laurie, Cathy C. ;

Nelson, Sarah ;

Li, Mary ;

Sanchez-Lara, Pedro A. ;

Magee, William P., III ;

Magee, Kathleen S. ;

Auslander, Allyn ;

Brindopke, Frederick ;

Kay, Denise M. ;

Caggana, Michele ;

Romitti, Paul A. ;

Mills, James L. ;

Audu, Rosemary ;

Onwuamah, Chika ;

Oseni, Ganiyu O. ;

Owais, Arwa ;

James, Olutayo ;

Olaitan, Peter B. ;

Aregbesola, Babatunde S. ;

Braimah, Ramat O. ;

Oginni, Fadekemi O. ;

Oladele, Ayodeji O. ;

Bello, Saidu A. ;

Rhodes, Jennifer ;

Shiang, Rita ;

Donkor, Peter ;

Obiri-Yeboah, Solomon ;

Arthur, Fareed Kow Nanse ;

Twumasi, Peter ;

Agbenorku, Pius ;

Plange-Rhule, Gyikua ;

Oti, Alexander Acheampong ;

Ogunlewe, Olugbenga M. ;

Oladega, Afisu A. ;

Adekunle, Adegbayi A. ;

Erinoso, Akinwunmi O. ;

Adamson, Olatunbosun O. ;

Elufowoju, Abosede A. ;

Ayelomi, Oluwanifemi I. ;

Hailu, Taiye .

HUMAN MOLECULAR GENETICS, 2019, 28 (06) :1038-1051

[7] Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate [J].

Cox, Liza L. ;

Cox, Timothy C. ;

Uribe, Lina M. Moreno ;

Zhu, Ying ;

Richter, Chika T. ;

Nidey, Nichole ;

Standley, Jennifer M. ;

Deng, Mei ;

Blue, Elizabeth ;

Chong, Jessica X. ;

Yang, Yueqin ;

Carstens, Russ P. ;

Anand, Deepti ;

Lachke, Salil A. ;

Smith, Joshua D. ;

Dorschner, Michael O. ;

Bedell, Bruce ;

Kirk, Edwin ;

Hing, Anne, V ;

Venselaar, Hanka ;

Valencia-Ramirez, Luz C. ;

Bamshad, Michael J. ;

Glass, Ian A. ;

Cooper, Jonathan A. ;

Haan, Eric ;

Nickerson, Deborah A. ;

van Bokhoven, Hans ;

Zhou, Huiqing ;

Krahn, Katy N. ;

Buckley, Michael F. ;

Murray, Jeffrey C. ;

Lidral, Andrew C. ;

Roscioli, Tony .

AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 102 (06) :1143-1157

[8] A Novel CDH1 Mutation Causing Reduced E-Cadherin Dimerization Is Associated with Nonsyndromic Cleft Lip With or Without Cleft Palate [J].

Du, Shiyue ;

Yang, Yujie ;

Yi, Ping ;

Luo, Junyu ;

Liu, Teng ;

Chen, Rui ;

Liu, Chun-jie ;

Ma, Tingbin ;

Li, Yulei ;

Wang, Cheng ;

Weng, Jun ;

Liu, Mugen ;

Zhang, Luoying ;

Yang, Baosheng ;

Zeng, Xiaomei ;

Liu, Jing Yu .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2019, 23 (11) :759-765

[9] Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer [J].

Frebourg, T ;

Oliveira, C ;

Hochain, P ;

Karam, R ;

Manouvrier, S ;

Graziadio, C ;

Vekemans, M ;

Hartmann, A ;

Baert-Desurmont, S ;

Alexandre, C ;

Dumoulin, SL ;

Marroni, C ;

Martin, C ;

Castedo, S ;

Lovett, M ;

Winston, J ;

Machado, JC ;

Attié, T ;

Jabs, EW ;

Cai, J ;

Pellerin, P ;

Triboulet, JP ;

Scotte, M ;

Le Pessot, F ;

Hedouin, A ;

Carneiro, F ;

Blayau, M ;

Seruca, R .

JOURNAL OF MEDICAL GENETICS, 2006, 43 (02) :138-142

[10] Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations [J].

Gowans, L. J. J. ;

Adeyemo, W. L. ;

Eshete, M. ;

Mossey, P. A. ;

Busch, T. ;

Aregbesola, B. ;

Donkor, P. ;

Arthur, F. K. N. ;

Bello, S. A. ;

Martinez, A. ;

Li, M. ;

Augustine-Akpan, E. A. ;

Deressa, W. ;

Twumasi, P. ;

Olutayo, J. ;

Deribew, M. ;

Agbenorku, P. ;

Oti, A. A. ;

Braimah, R. ;

Plange-Rhule, G. ;

Gesses, M. ;

Obiri-Yeboah, S. ;

Oseni, G. O. ;

Olaitan, P. B. ;

Abdur-Rahman, L. ;

Abate, F. ;

Hailu, T. ;

Gravem, P. ;

Ogunlewe, M. O. ;

Buxo, C. J. ;

Marazita, M. L. ;

Adeyemo, A. A. ;

Murray, J. C. ;

Butali, A. .

JOURNAL OF DENTAL RESEARCH, 2016, 95 (11) :1245-1256

← 1 2 3 4 →

共 38 条

[1] A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 [J].

Beaty, Terri H. ;

Murray, Jeffrey C. ;

Marazita, Mary L. ;

Munger, Ronald G. ;

Ruczinski, Ingo ;

Hetmanski, Jacqueline B. ;

Liang, Kung Yee ;

Wu, Tao ;

Murray, Tanda ;

Fallin, M. Daniele ;

Redett, Richard A. ;

Raymond, Gerald ;

Schwender, Holger ;

Jin, Sheng-Chih ;

Cooper, Margaret E. ;

Dunnwald, Martine ;

Mansilla, Maria A. ;

Leslie, Elizabeth ;

Bullard, Stephen ;

Lidral, Andrew C. ;

Moreno, Lina M. ;

Menezes, Renato ;

Vieira, Alexandre R. ;

Petrin, Aline ;

Wilcox, Allen J. ;

Lie, Rolv T. ;

Jabs, Ethylin W. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Wang, Hong ;

Ye, Xiaoqian ;

Huang, Shangzhi ;

Yeow, Vincent ;

Chong, Samuel S. ;

Jee, Sun Ha ;

Shi, Bing ;

Christensen, Kaare ;

Melbye, Mads ;

Doheny, Kimberly F. ;

Pugh, Elizabeth W. ;

Ling, Hua ;

Castilla, Eduardo E. ;

Czeizel, Andrew E. ;

Ma, Lian ;

Field, L. Leigh ;

Brody, Lawrence ;

Pangilinan, Faith ;

Mills, James L. ;

Molloy, Anne M. ;

Kirke, Peadar N. .

NATURE GENETICS, 2010, 42 (06) :525-U76

[2] Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24 [J].

Birnbaum, Stefanie ;

Ludwig, Kerstin U. ;

Reutter, Heiko ;

Herms, Stefan ;

Steffens, Michael ;

Rubini, Michele ;

Baluardo, Carlotta ;

Ferrian, Melissa ;

de Assis, Nilma Almeida ;

Alblas, Margrieta A. ;

Barth, Sandra ;

Freudenberg, Jan ;

Lauster, Carola ;

Schmidt, Guel ;

Scheer, Martin ;

Braumann, Bert ;

Berge, Stefaan J. ;

Reich, Rudolf H. ;

Schiefke, Franziska ;

Hemprich, Alexander ;

Poetzsch, Simone ;

Steegers-Theunissen, Regine P. ;

Poetzsch, Bernd ;

Moebus, Susanne ;

Horsthemke, Bernhard ;

Kramer, Franz-Josef ;

Wienker, Thomas F. ;

Mossey, Peter A. ;

Propping, Peter ;

Cichon, Sven ;

Hoffmann, Per ;

Knapp, Michael ;

Noethen, Markus M. ;

Mangold, Elisabeth .

NATURE GENETICS, 2009, 41 (04) :473-477

[3] Genome-wide Enrichment of De Novo Coding Mutations in Orofacial Cleft Trios [J].

Bishop, Madison R. ;

Perez, Kimberly K. Diaz ;

Sun, Miranda ;

Ho, Samantha ;

Chopra, Pankaj ;

Mukhopadhyay, Nandita ;

Hetmanski, Jacqueline B. ;

Taub, Margaret A. ;

Moreno-Uribe, Lina M. ;

Valencia-Ramirez, Luz Consuelo ;

Restrepo Muneton, Claudia P. ;

Wehby, George ;

Hecht, Jacqueline T. ;

Deleyiannis, Frederic ;

Weinberg, Seth M. ;

Wu-Chou, Yah Huei ;

Chen, Philip K. ;

Brand, Harrison ;

Epstein, Michael P. ;

Ruczinski, Ingo ;

Murray, Jeffrey C. ;

Beaty, Terri H. ;

Feingold, Eleanor ;

Lipinski, Robert J. ;

Cutler, David J. ;

Marazita, Mary L. ;

Leslie, Elizabeth J. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2020, 107 (01) :124-136

[4] Rare Variants in the Epithelial Cadherin Gene Underlying the Genetic Etiology of Nonsyndromic Cleft Lip with or without Cleft Palate [J].

Brito, Luciano Abreu ;

Yamamoto, Guilherme Lopes ;

Melo, Soraia ;

Malcher, Carolina ;

Ferreira, Simone Gomes ;

Figueiredo, Joana ;

Alvizi, Lucas ;

Kobayashi, Gerson Shigeru ;

Naslavsky, Michel Satya ;

Alonso, Nivaldo ;

Felix, Temis Maria ;

Zatz, Mayana ;

Seruca, Raquel ;

Passos-Bueno, Maria Rita .

HUMAN MUTATION, 2015, 36 (11) :1029-1033

[5] Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts [J].

Bureau, Alexandre ;

Parker, Margaret M. ;

Ruczinski, Ingo ;

Taub, Margaret A. ;

Marazita, Mary L. ;

Murray, Jeffrey C. ;

Mangold, Elisabeth ;

Noethen, Markus M. ;

Ludwig, Kirsten U. ;

Hetmanski, Jacqueline B. ;

Bailey-Wilson, Joan E. ;

Cropp, Cheryl D. ;

Li, Qing ;

Szymczak, Silke ;

Albacha-Hejazi, Hasan ;

Alqosayer, Khalid ;

Field, L. Leigh ;

Wu-Chou, Yah-Huei ;

Doheny, Kimberly F. ;

Ling, Hua ;

Scott, Alan F. ;

Beaty, Terri H. .

GENETICS, 2014, 197 (03) :1039-+

[6] Genomic analyses in African populations identify novel risk loci for cleft palate [J].

Butali, Azeez ;

Mossey, Peter A. ;

Adeyemo, Wasiu L. ;

Eshete, Mekonen A. ;

Gowans, Lord J. J. ;

Busch, Tamara D. ;

Jain, Deepti ;

Yu, Wenjie ;

Huan, Liu ;

Laurie, Cecelia A. ;

Laurie, Cathy C. ;

Nelson, Sarah ;

Li, Mary ;

Sanchez-Lara, Pedro A. ;

Magee, William P., III ;

Magee, Kathleen S. ;

Auslander, Allyn ;

Brindopke, Frederick ;

Kay, Denise M. ;

Caggana, Michele ;

Romitti, Paul A. ;

Mills, James L. ;

Audu, Rosemary ;

Onwuamah, Chika ;

Oseni, Ganiyu O. ;

Owais, Arwa ;

James, Olutayo ;

Olaitan, Peter B. ;

Aregbesola, Babatunde S. ;

Braimah, Ramat O. ;

Oginni, Fadekemi O. ;

Oladele, Ayodeji O. ;

Bello, Saidu A. ;

Rhodes, Jennifer ;

Shiang, Rita ;

Donkor, Peter ;

Obiri-Yeboah, Solomon ;

Arthur, Fareed Kow Nanse ;

Twumasi, Peter ;

Agbenorku, Pius ;

Plange-Rhule, Gyikua ;

Oti, Alexander Acheampong ;

Ogunlewe, Olugbenga M. ;

Oladega, Afisu A. ;

Adekunle, Adegbayi A. ;

Erinoso, Akinwunmi O. ;

Adamson, Olatunbosun O. ;

Elufowoju, Abosede A. ;

Ayelomi, Oluwanifemi I. ;

Hailu, Taiye .

HUMAN MOLECULAR GENETICS, 2019, 28 (06) :1038-1051

[7] Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate [J].

Cox, Liza L. ;

Cox, Timothy C. ;

Uribe, Lina M. Moreno ;

Zhu, Ying ;

Richter, Chika T. ;

Nidey, Nichole ;

Standley, Jennifer M. ;

Deng, Mei ;

Blue, Elizabeth ;

Chong, Jessica X. ;

Yang, Yueqin ;

Carstens, Russ P. ;

Anand, Deepti ;

Lachke, Salil A. ;

Smith, Joshua D. ;

Dorschner, Michael O. ;

Bedell, Bruce ;

Kirk, Edwin ;

Hing, Anne, V ;

Venselaar, Hanka ;

Valencia-Ramirez, Luz C. ;

Bamshad, Michael J. ;

Glass, Ian A. ;

Cooper, Jonathan A. ;

Haan, Eric ;

Nickerson, Deborah A. ;

van Bokhoven, Hans ;

Zhou, Huiqing ;

Krahn, Katy N. ;

Buckley, Michael F. ;

Murray, Jeffrey C. ;

Lidral, Andrew C. ;

Roscioli, Tony .

AMERICAN JOURNAL OF HUMAN GENETICS, 2018, 102 (06) :1143-1157

[8] A Novel CDH1 Mutation Causing Reduced E-Cadherin Dimerization Is Associated with Nonsyndromic Cleft Lip With or Without Cleft Palate [J].

Du, Shiyue ;

Yang, Yujie ;

Yi, Ping ;

Luo, Junyu ;

Liu, Teng ;

Chen, Rui ;

Liu, Chun-jie ;

Ma, Tingbin ;

Li, Yulei ;

Wang, Cheng ;

Weng, Jun ;

Liu, Mugen ;

Zhang, Luoying ;

Yang, Baosheng ;

Zeng, Xiaomei ;

Liu, Jing Yu .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2019, 23 (11) :759-765

[9] Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer [J].

Frebourg, T ;

Oliveira, C ;

Hochain, P ;

Karam, R ;

Manouvrier, S ;

Graziadio, C ;

Vekemans, M ;

Hartmann, A ;

Baert-Desurmont, S ;

Alexandre, C ;

Dumoulin, SL ;

Marroni, C ;

Martin, C ;

Castedo, S ;

Lovett, M ;

Winston, J ;

Machado, JC ;

Attié, T ;

Jabs, EW ;

Cai, J ;

Pellerin, P ;

Triboulet, JP ;

Scotte, M ;

Le Pessot, F ;

Hedouin, A ;

Carneiro, F ;

Blayau, M ;

Seruca, R .

JOURNAL OF MEDICAL GENETICS, 2006, 43 (02) :138-142

[10] Association Studies and Direct DNA Sequencing Implicate Genetic Susceptibility Loci in the Etiology of Nonsyndromic Orofacial Clefts in Sub-Saharan African Populations [J].

Gowans, L. J. J. ;

Adeyemo, W. L. ;

Eshete, M. ;

Mossey, P. A. ;

Busch, T. ;

Aregbesola, B. ;

Donkor, P. ;

Arthur, F. K. N. ;

Bello, S. A. ;

Martinez, A. ;

Li, M. ;

Augustine-Akpan, E. A. ;

Deressa, W. ;

Twumasi, P. ;

Olutayo, J. ;

Deribew, M. ;

Agbenorku, P. ;

Oti, A. A. ;

Braimah, R. ;

Plange-Rhule, G. ;

Gesses, M. ;

Obiri-Yeboah, S. ;

Oseni, G. O. ;

Olaitan, P. B. ;

Abdur-Rahman, L. ;

Abate, F. ;

Hailu, T. ;

Gravem, P. ;

Ogunlewe, M. O. ;

Buxo, C. J. ;

Marazita, M. L. ;

Adeyemo, A. A. ;

Murray, J. C. ;

Butali, A. .

JOURNAL OF DENTAL RESEARCH, 2016, 95 (11) :1245-1256

← 1 2 3 4 →