Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view

被引：46

作者：

Huart, Caroline ^{[1
,2
]}

Philpott, Carl M. ^{[3
,4
]}

Altundag, Aytug ^{[5
]}

Fjaeldstad, Alexander W. ^{[6
,7
]}

Frasnelli, Johannes ^{[8
]}

Gane, Simon ^{[9
,10
]}

Hsieh, Julien W. ^{[11
]}

Holbrook, Eric H. ^{[12
]}

Konstantinidis, Iordanis ^{[13
]}

Landis, Basile N. ^{[11
]}

Macchi, Alberto ^{[14
]}

Mueller, Christian A. ^{[15
]}

Negoias, Simona ^{[16
]}

Pinto, Jayant M. ^{[17
]}

Poletti, Sophia C. ^{[18
]}

Ramakrishnan, Vijay R. ^{[19
]}

Rombaux, Philippe ^{[1
,2
]}

Vodicka, Jan ^{[20
]}

Welge-Luessen, Antje ^{[16
]}

Whitcroft, Katherine L. ^{[10
,21
]}

Hummel, Thomas ^{[22
]}

机构：

[1] Clin Univ St Luc, Dept Otorhinolaryngol, Brussels, Belgium

[2] Catholic Univ Louvain, Inst Neurosci, Brussels, Belgium

[3] Norfolk & Waveney ENT Serv, Norfolk Smell & Taste Clin, Gorleston, England

[4] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England

[5] Biruni Univ, Dept Otorhinolaryngol, Istanbul, Turkey

[6] Reg Hosp West Jutland, Dept Otorhinolaryngol, Flavour Clin, Holstebro, Denmark

[7] Aarhus Univ, Flavour Inst, Aarhus, Denmark

[8] Univ Quebec Trois Rivieres, Dept Anat, Trois Rivieres, PQ, Canada

[9] Univ Coll London Hosp NHS Fdn Trust, Royal Natl ENT Hosp, Dept Rhinol, London, England

[10] UCL, UCL Ear Inst, London, England

[11] Geneva Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Rhinol Olfactory Unit, Geneva, Switzerland

[12] Harvard Univ, Massachusetts Eye & Ear, Boston, MA USA

[13] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Acad ORL Dept 2, Thessaloniki, Greece

[14] Univ Insubriae, ENT Clin Asst Settelaghi, Varese, Italy

[15] Med Univ Vienna, Dept Otorhinolaryngol, Vienna, Austria

[16] Univ Hosp Basel, Dept Otorhinolaryngol Head & Neck Surg, CH-4051 Basel, Switzerland

[17] Univ Chicago, Sect Otolaryngol Head & Neck Surg, Chicago, IL USA

[18] Univ Hosp Bern, Dept Otorhinolaryngol, Inselspital, Bern, Switzerland

[19] Univ Colorado, Dept Otolaryngol Head & Neck Surg, Anschutz Med Campus, Aurora, CO USA

[20] Hosp Pardubice, Dept Otorhinolaryngol & Head & Neck Surg, Pardubice, Czech Republic

[21] Sch Adv Study, Inst Philosophy, Ctr Olfactory Res & Applicat, London, England

[22] Tech Univ Dresden, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany

来源：

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY | 2021年 / 11卷 / 07期

关键词：

corticosteroids; COVID-19; olfaction disorder; SARS-CoV-2; smell;

D O I：

10.1002/alr.22788

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The frequent association between coronavirus disease 2019 (COVID-19) and olfactory dysfunction is creating an unprecedented demand for a treatment of the olfactory loss. Systemic corticosteroids have been considered as a therapeutic option. However, based on current literature, we call for caution using these treatments in early COVID-19-related olfactory dysfunction because: (1) evidence supporting their usefulness is weak; (2) the rate of spontaneous recovery of COVID-19-related olfactory dysfunction is high; and (3) corticosteroids have well-known potential adverse effects. We encourage randomized placebo-controlled trials investigating the efficacy of systemic steroids in this indication and strongly emphasize to initially consider smell training, which is supported by a robust evidence base and has no known side effects.

引用

页码：1041 / 1046

页数：6

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