Diabetes - Outfoxing insulin resistance?

被引:18
作者
Montminy, M [1 ]
Koo, SH [1 ]
机构
[1] Salk Inst Biol Studies, La Jolla, CA 92130 USA
关键词
D O I
10.1038/432958a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Resistance to insulin predisposes people to diabetes; it is characterized by increased storage of fats and a failure to stop glucose synthesis. The molecular underpinnings of these effects have been uncovered.
引用
收藏
页码:958 / 959
页数:2
相关论文
共 4 条
[1]   Insulin signalling and the regulation of glucose and lipid metabolism [J].
Saltiel, AR ;
Kahn, CR .
NATURE, 2001, 414 (6865) :799-806
[2]   Biological control through regulated transcriptional coactivators [J].
Spiegelman, BM ;
Heinrich, R .
CELL, 2004, 119 (02) :157-167
[3]   The IRS-signalling system: A network of docking proteins that mediate insulin action [J].
White, MF .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1998, 182 (1-2) :3-11
[4]   Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes [J].
Wolfrum, C ;
Asilmaz, E ;
Luca, E ;
Friedman, JM ;
Stoffel, M .
NATURE, 2004, 432 (7020) :1027-1032