Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties

被引：26
作者：
Ma, Guobin
Delorme, Jean-Francois
Gallant, Pascal
Boas, David A.
机构：
[1] Adv Res Technol Inc, St Laurent, PQ H4S 2A4, Canada
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
来源：
APPLIED OPTICS | 2007年 / 46卷 / 10期
关键词：
PHOTON MIGRATION; RADIATIVE-TRANSFER; TURBID MEDIUM; MEDIA; LIGHT; MODEL; TOMOGRAPHY; SCATTERING; EQUATION; RECONSTRUCTION;
D O I：
10.1364/AO.46.001686
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A simplified approach is proposed to simulate the fluorescence signal from a fluorophore submerged inside a turbid medium using the Monte Carlo method. Based on the reversibility of photon propagation, the fluorescence signal can be obtained from a single Monte Carlo simulation of the excitation light. This is computationally less expensive and also allows for the direct use of well-validated nonfluorescence photon migration Monte Carlo codes. Fluorescence signals from a mouse tissuelike phantom were computed using both the simplified Monte Carlo simulation and the diffusion approximation. The relative difference of signal intensity was found to be at most 30% for a fluorophore placed in the medium at various depths and horizontally midway between a source-detector pair separated by 3 mm. The difference in time characteristics of the signal is also examined. (c) 2007 Optical Society of America.
引用
收藏
页码：1686 / 1692
页数：7
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