From studies on artemisinin derivatives to trioxaquines

被引：4
作者：
Meunier, B [1 ]
机构：
[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France
来源：
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES | 2002年 / 6卷 / 04期
关键词：
malaria; artemisinin; trioxaquine;
D O I：
10.1142/S1088424602000312
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Heme, resulting from hemoglobin digestion by the malaria parasite is one of the main, target of antimalarial drugs like chloroquine and artemisinin. This later molecule contains a trioxane which is activated by the reduced form of heme to generate a strong alkylating agent able to react with heme itself. Taking advantage of these studies, we prepared new antimalarial drugs, trioxaquines, containing a trioxane motif covalently linked to an aminoquinoline. Copyright (C) 2002 Society of Porphyrins & Phthalocyanines.
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收藏
页码：271 / 273
页数：3
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