Phosphine-catalyzed [4+1] annulation of 1,3-(aza)dienes with maleimides: highly efficient construction of azaspiro[4.4]nonenes

被引：37
|
作者：
Yang, Mei
Wang, Tianyi
Cao, Shixuan
He, Zhengjie [1 ]
机构：
[1] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 88期
基金：
中国国家自然科学基金;
关键词：
ISOXAZOLINE N-OXIDES; ANTICONVULSANT ACTIVITY; HILLMAN CARBONATES; PHOSPHORUS YLIDES; SULFONIUM YLIDES; FORMAL SYNTHESIS; SULFUR YLIDES; DERIVATIVES; ENONES; 2,3-DIHYDROFURANS;
D O I：
10.1039/c4cc05624h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Phosphine-catalyzed [4+1] annulation of electron-deficient 1,3-dienes or 1,3-azadienes with maleimides has been successfully developed under very mild conditions, providing a convenient and highly efficient method for constructing 2-azaspiro[4.4]nonenes and 1,7-diazaspiro[4.4]nonenes. This reaction represents the first example of [4+1] cyclization between electron-deficient 4 pi-conjugated systems and non-allylic phosphorus ylides.
引用
收藏
页码：13506 / 13509
页数：4
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