Class I MHC Polymorphisms Associated with Type 2 Diabetes in the Mexican Population

被引：3

作者：

Mendoza-Ramirez, Paola ^{[1
]}

Alejandra Lopez-Olaiz, Mildred ^{[2
]}

Lizeth Morales-Fernandez, Adriana ^{[3
]}

Isabel Flores-Echiveste, Maria ^{[3
]}

de Jesus Casillas-Navarro, Antonio ^{[3
]}

Andres Perez-Rodriguez, Marco ^{[4
,5
]}

de Jesus Orozco-Luna, Felipe ^{[4
,5
]}

Cortes-Romero, Celso ^{[6
]}

Yareni Zuniga, Laura ^{[3
,4
,5
,7
]}

Sanchez Parada, Maria Guadalupe ^{[3
,4
,5
,7
]}

Daniel Hernandez-Ortega, Luis ^{[8
,9
]}

Roldan Mercado-Sesma, Arieh ^{[7
,10
]}

Baptista-Rosas, Raul C. ^{[7
,10
,11
]}

机构：

[1] Benemerita Univ Autonoma Puebla, Fac Ciencias Biol, Puebla 72570, Mexico

[2] Univ Valle Atemajac, Escuela Nutr, Zapopan 45037, Mexico

[3] Univ Guadalajara, Ctr Univ Tonala, Escuela Med, Tonala 45425, Mexico

[4] Univ Guadalajara, Programa Doctorado Tecnol Informac, Zapopan 45100, Mexico

[5] Univ Guadalajara, Ctr Andlisis Datos & Supercomputo, Zapopan 45100, Mexico

[6] Univ Guadalajara, Ctr Univ Ciencias Exactas & Ingn, Dept Quim, Guadalajara 44430, Jalisco, Mexico

[7] Univ Guadalajara, Ctr Univ Tonala, Ctr Invest Multidisciplinaria Salud, Tonala 45425, Mexico

[8] Univ Guadalajara, Ctr Univ Tonala, Dept Ciencias Biomed, Tonala 45425, Mexico

[9] Ctr Univ UTEG, Dept Invest, Guadalajara 44460, Jalisco, Mexico

[10] Univ Guadalajara, Ctr Univ Tonala, Dept Ciencias Salud Enfermedad Como Proc Individu, Tonala 45425, Mexico

[11] Hosp Gen Occidente Seguro Social, Secretaria Salud Jalisco, Zapopan 45170, Mexico

来源：

GENES | 2022年 / 13卷 / 05期

关键词：

HLA; MHC class I; polymorphism; variant; type; 2; diabetes; Mexican; HLA ANTIGENS; GENE-A; MELLITUS; SUSCEPTIBILITY; ALLELES; METFORMIN; ADULTS; LOCUS; NIDDM;

D O I：

10.3390/genes13050772

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Type 2 diabetes (T2D) has been linked to the expression of Human Leukocyte Antigens, principally to the Major Histocompatibility Complex Class II, with only scarce reports of Major Histocompatibility Complex Class I in specific populations. The objective of the present work was to explore the presence of polymorphisms in the MHC Class I related to T2D in the Mexican population using the Genome-Wide Association Studies Slim Initiative in Genomic Medicine of the Americas (GWAS SIGMA) database. This database contains information on 3848 Mexican individuals with T2D and 4366 control individuals from the same population without a clinical or hereditary history of the disease. The searching criteria considered a p-value of <0.005 and an odds ratio (OR) of >1.0. Ten novel, statistically significant nucleotide variants were identified: four polymorphisms associated with HLA-A (A*03:01:01:01) and six with HLA-C (C*01:02:01:01). These alleles have a high prevalence in Latin American populations and could potentially be associated with autoimmunity mechanisms related to the development of T2D complications.

引用

页数：10

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