Prognostic value of interim 18F-FDG PET/CT in T-cell lymphomas

被引：9

作者：

Qian, Long ^{[1
]}

Yan, Miaoming ^{[1
]}

Zhang, Wei ^{[1
]}

Zhou, Daobin ^{[1
]}

Zhang, Yan ^{[1
]}

Huo, Li ^{[2
]}

Luo, Yaping ^{[2
]}

Zhang, Yingqiang ^{[2
]}

Hu, Shaoxuan ^{[1
]}

机构：

[1] Peking Union Med Coll Hosp, Dept Hematol, Beijing 100730, Peoples R China

[2] Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2020年 / 61卷 / 04期

关键词：

Interim PET; CT; T-cell lymphomas; prognostic value; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; RESPONSE ASSESSMENT; INTERNATIONAL WORKSHOP; HODGKIN-LYMPHOMA; ADAPTED THERAPY; CONSENSUS; IMPROVES; SCANS; CT;

D O I：

10.1080/10428194.2019.1697815

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

18F-FDG PET/CT is recommended for staging and response assessment in FDG-avid lymphomas, such as HL and DLBCL. But evidence of PET/CT regarding T-cell lymphomas (TCLs) was limited. In this retrospective study, we conducted survival analysis using interim PET/CT in 51 TCLs patients. PET/CT were reported using the Deauville 5-point score (DS) and the Delta SUVmax. In univariate analysis, I-PET/CT had a significant prognostic value of survival outcomes based on DS (p < .001 for progression-free survival (PFS), p = .010 for overall survival (OS)) and Delta SUVmax (p < .001 for PFS, p = .023 for OS). In multivariate analysis, DS remained a statistically independent predictor of PFS (p < .001) and OS (p = .017). Delta SUVmax remained a statistically independent predictor of PFS (p = .008), but not of OS (p = 0.311). Therefore, DS on I-PET/CT had a remarkable value of predicting survival outcomes in TCLs.

引用

页码：927 / 933

页数：7

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