Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer

被引：121

作者：

Kulasingam, Vathany ^{[1
,2
]}

Pavlou, Maria P. ^{[1
,2
]}

Diamandis, Eleftherios P. ^{[1
,2
,3
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5G 1X5, Canada

[2] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

[3] Univ Hlth Network, Dept Clin Biochem, Toronto, ON M5G 2C4, Canada

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 05期

关键词：

GRANULIN-EPITHELIN PRECURSOR; PROTEOMIC ANALYSIS; BREAST-CANCER; MASS-SPECTROMETRY; GROWTH-FACTOR; MALIGNANT ASCITES; SERUM; DISCOVERY; PROTEIN; PLASMA;

D O I：

10.1038/nrc2831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite widespread interest, few serum biomarkers have been introduced to the clinic over the past 20 years. Each approach to ovarian cancer biomarker discovery has its own advantages and disadvantages and it seems likely that a global biomarker discovery platform that mines all possible sources for biomarkers might be more useful. such data could be combined with information from relevant microarray data, bioinformatic analyses and literature searches. This proposed integrated systems biology approach has the potential to yield promising ovarian cancer markers for diagnosis, prognosis and monitoring of patients during therapy.

引用

页码：371 / 378

页数：9

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