Transition-metal-free nucleophilic 211At-astatination of spirocyclic aryliodonium ylides

被引：11

作者：

Matsuoka, Keitaro ^{[1
]}

Obata, Honoka ^{[1
,2
]}

Nagatsu, Kotaro ^{[2
]}

Kojima, Masahiro ^{[1
]}

Yoshino, Tatsuhiko ^{[1
]}

Ogawa, Mikako ^{[1
,3
]}

Matsunaga, Shigeki ^{[1
,3
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Natl Inst Quantum & Radiol Sci & Technol, Dept Adv Nucl Med Sci, Inst Quantum Med Sci, Chiba 2638555, Japan

[3] Hokkaido Univ, Global Stn Biosurfaces & Drug Discovery, Sapporo, Hokkaido 0600812, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 25期

关键词：

IODONIUM YLIDES; RADIOFLUORINATION; SUBSTITUTION; RADIOIODINATION; RADIOHALOGENS; ASTATINATION; CHEMISTRY; BEHAVIOR; STEP;

D O I：

10.1039/d1ob00789k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The transition-metal-free At-211-astatination of spirocyclic aryliodonium ylides via a nucleophilic aromatic substitution reaction is described. This method enables the preparation of At-211-radiolabeled compounds derived from multi-functionalized molecules and heteroarenes in good to excellent radiochemical yields.

引用

页码：5525 / 5528

页数：4

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