Is the glutathione S-conjugate pump a flippase?

被引：0

作者：

Sokal, A ^{[1
]}

Pulaski, L ^{[1
]}

Rychlik, B ^{[1
]}

Fortuniak, A ^{[1
]}

Bartosz, G ^{[1
]}

机构：

[1] Univ Lodz, Dept Mol Biophys, PL-90237 Lodz, Poland

来源：

BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1998年 / 44卷 / 01期

关键词：

glutathione conjugates; MRP; membrane; transport; erythrocyte; flippase;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A hypothesis of the flippase nature of the glutathione S-conjugate transport is presented. Experimental premises for this hypothesis include interaction of glutathione S-conjugates with the membrane, as demonstrated by their effects on membrane fluidity, quenching of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene fluorescence and induction of echinocytosis by 2,4-dinitrophenyl-S-glutathione (DNP-SG). This hypothesis can rationalize, i. a., observations of the enhancement of DNP-SG transport by butanol and stimulation of erythrocyte membrane Mg2+-ATPase activity by albumin-coupled DNP-SG.

引用

页码：97 / 105

页数：9

共 35 条

[1]

AKERBOOM TPM, 1991, J BIOL CHEM, V266, P13147

[2] LOW-K(M) AND HIGH-K(M) TRANSPORT OF DINITROPHENYL GLUTATHIONE IN INSIDE OUT VESICLES FROM HUMAN ERYTHROCYTES [J].