Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology

被引：69
|
作者：
Credito, Kim [1 ]
Lin, Gengrong [1 ]
Appelbaum, Peter C. [1 ]
机构：
[1] Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期
关键词：
D O I：
10.1128/AAC.01455-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 mu g/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.
引用
收藏
页码：1504 / 1507
页数：4
相关论文
共 50 条
  • [1] In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods
    Jacqueline, C
    Caillon, J
    Le Mabecque, V
    Miègeville, AF
    Donnio, PY
    Bugnon, D
    Potel, G
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (04) : 857 - 864
  • [2] In vitro time-kill activities of rifalazil, alone and in combination with vancomycin, against logarithmic and stationary cultures of Staphylococcus aureus
    Osburne, MS
    Rothstein, DM
    Farquhar, R
    Murphy, CK
    JOURNAL OF ANTIBIOTICS, 2006, 59 (02): : 80 - 85
  • [3] In Vitro Time-kill Activities of Rifalazil, Alone and in Combination with Vancomycin, against Logarithmic and Stationary Cultures of Staphylococcus aureus
    Marcia S Osburne
    David M Rothstein
    Ronnie Farquhar
    Christopher K Murphy
    The Journal of Antibiotics, 2006, 59 : 80 - 85
  • [4] Assessment by time-kill methodology of the synergistic effects of oritavancin in combination with other antimicrobial agents against Staphylococcus aureus
    Belley, Adam
    Neesham-Grenon, Eve
    Arhin, Francis F.
    Mckay, Geoffrey A.
    Parr, Thomas R., Jr.
    Moeck, Gregory
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) : 3820 - 3822
  • [5] Antimicrobial activities of daptomycin, vancomycin, and oxacillin in human monocytes and of daptomycin in combination with gentamicin and/or rifampin in human monocytes and in broth against Staphylococcus aureus
    Baltch, Aldona L.
    Ritz, William J.
    Bopp, Lawrence H.
    Michelsen, Phyllis B.
    Smith, Raymond P.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (04) : 1559 - 1562
  • [6] Evaluation of daptomycin, vancomycin, teicoplanin and linezolid against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium utilizing in-vitro time-kill methodology
    Brauers, J.
    Kresken, M.
    Dahmen, V.
    Menke, A.
    Weiher, H.
    Morrissey, I.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2006, 296 : 109 - 110
  • [7] Activity of Trovafloxacin, Alone and in Combination with Other Agents, Against Enterobacteriaceae by Time-Kill Analysis
    C. L. Clark
    L. M. Kelly
    M. R. Jacobs
    P. C. Appelbaum
    European Journal of Clinical Microbiology and Infectious Diseases, 2000, 19 : 565 - 567
  • [8] Activity of trovafloxacin, alone and in combination with other agents, against Enterobacteriaceae by time-kill analysis
    Clark, CL
    Kelly, LM
    Jacobs, MR
    Appelbaum, PC
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2000, 19 (07) : 565 - 567
  • [9] Activities of Daptomycin and Vancomycin Alone and in Combination with Rifampin and Gentamicin against Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Isolates in an Experimental Model of Endocarditis
    LaPlante, Kerry L.
    Woodmansee, Suzanne
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (09) : 3880 - 3886
  • [10] In Vitro Activity of Daptomycin in Combination with β-Lactams, Gentamicin, Rifampin, and Tigecycline against Daptomycin-Nonsusceptible Enterococci
    Hindler, Janet A.
    Wong-Beringer, Annie
    Charlton, Carmen L.
    Miller, Shelley A.
    Kelesidis, Theodoros
    Carvalho, Marissa
    Sakoulas, George
    Nonejuie, Poochit
    Pogliano, Joseph
    Nizet, Victor
    Humphries, Romney
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (07) : 4279 - 4288
12345