Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials

被引：544
作者：
Broderick, Joseph P. [1 ]
Adeoye, Opeolu [2 ]
Elm, Jordan [3 ]
机构：
[1] Univ Cincinnati, Gardner Neurosci Inst, Dept Neurol & Rehabil Med, 260 Stetson St,Suite 2300,POB 670525, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Gardner Neurosci Inst, Dept Emergency Med, Cincinnati, OH 45267 USA
[3] Med Univ South Carolina, Div Biostat, Charleston, SC USA
来源：
STROKE | 2017年 / 48卷 / 07期
关键词：
clinical trial; modified Rankin Scale; multimedia; stroke; ACUTE ISCHEMIC-STROKE; INITIAL CONSERVATIVE TREATMENT; INTRAVENOUS T-PA; INTRACEREBRAL HEMATOMAS; STATISTICAL-ANALYSIS; EARLY SURGERY; THROMBECTOMY; INTRAARTERIAL; HEMORRHAGE; ALTEPLASE;
D O I：
10.1161/STROKEAHA.117.017866
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The mRS has evolved as the primary outcome measure for acute stroke trials. Other patient-centered outcome measures not discussed in this article, such as the Euro-QOL 5-D25 or Neuro-QOL,53 have complementary strengths and often are used as secondary outcomes, although none have yet to be used as the primary outcome measure in a positive acute stroke trial. This could change in the future. At present, attention to training and standardization of mRS assessments, use of UW-mRS or some equivalent patient-centered outcome, and careful selection of appropriate effect size based upon previous trials and expected distribution of outcomes are important for planning of future acute stroke trials. © 2017 American Heart Association, Inc.
引用
收藏
页码：2007 / 2012
页数：6
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