Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials

被引：592

作者：

Broderick, Joseph P. ^{[1
]}

Adeoye, Opeolu ^{[2
]}

Elm, Jordan ^{[3
]}

机构：

[1] Univ Cincinnati, Gardner Neurosci Inst, Dept Neurol & Rehabil Med, 260 Stetson St,Suite 2300,POB 670525, Cincinnati, OH 45267 USA

[2] Univ Cincinnati, Gardner Neurosci Inst, Dept Emergency Med, Cincinnati, OH 45267 USA

[3] Med Univ South Carolina, Div Biostat, Charleston, SC USA

来源：

STROKE | 2017年 / 48卷 / 07期

关键词：

clinical trial; modified Rankin Scale; multimedia; stroke; ACUTE ISCHEMIC-STROKE; INITIAL CONSERVATIVE TREATMENT; INTRAVENOUS T-PA; INTRACEREBRAL HEMATOMAS; STATISTICAL-ANALYSIS; EARLY SURGERY; THROMBECTOMY; INTRAARTERIAL; HEMORRHAGE; ALTEPLASE;

D O I：

10.1161/STROKEAHA.117.017866

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The mRS has evolved as the primary outcome measure for acute stroke trials. Other patient-centered outcome measures not discussed in this article, such as the Euro-QOL 5-D25 or Neuro-QOL,53 have complementary strengths and often are used as secondary outcomes, although none have yet to be used as the primary outcome measure in a positive acute stroke trial. This could change in the future. At present, attention to training and standardization of mRS assessments, use of UW-mRS or some equivalent patient-centered outcome, and careful selection of appropriate effect size based upon previous trials and expected distribution of outcomes are important for planning of future acute stroke trials. © 2017 American Heart Association, Inc.

引用

页码：2007 / 2012

页数：6

共 53 条

[1] Stroke Treatment Academic Industry Roundtable (STAIR) Recommendations for Maximizing the Use of Intravenous Thrombolytics and Expanding Treatment Options With Intra-arterial and Neuroprotective Therapies [J].

Albers, Gregory W. ;

Goldstein, Larry B. ;

Hess, David C. ;

Wechsler, Lawrence R. ;

Furie, Karen L. ;

Gorelick, Philip B. ;

Hurn, Patty ;

Liebeskind, David S. ;

Nogueira, Raul G. ;

Saver, Jeffrey L. .

STROKE, 2011, 42 (09) :2645-2650

[2]

Ali M, 2017, EUR STROKE J, V2, P70, DOI 10.1177/2396987316683780

[3] Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke [J].

Anderson, C. S. ;

Robinson, T. ;

Lindley, R. I. ;

Arima, H. ;

Lavados, P. M. ;

Lee, T. -H. ;

Broderick, J. P. ;

Chen, X. ;

Chen, G. ;

Sharma, V. K. ;

Kim, J. S. ;

Thang, N. H. ;

Cao, Y. ;

Parsons, M. W. ;

Levi, C. ;

Huang, Y. ;

Olavarria, V. V. ;

Demchuk, A. M. ;

Bath, P. M. ;

Donnan, G. A. ;

Martins, S. ;

Pontes-Neto, O. M. ;

Silva, F. ;

Ricci, S. ;

Roffe, C. ;

Pandian, J. ;

Billot, L. ;

Woodward, M. ;

Li, Q. ;

Wang, X. ;

Wang, J. ;

Chalmers, J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (24) :2313-2323

[4] Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial [J].

Anderson, Craig S. ;

Huang, Yining ;

Wang, Ji Guang ;

Arima, Hisatomi ;

Neal, Bruce ;

Peng, Bin ;

Heeley, Emma ;

Skulina, Christian ;

Parsons, Mark W. ;

Kim, Jong Sung ;

Tao, Qing Ling ;

Li, Yue Chun ;

Jiang, Jian Dong ;

Tai, Li Wen ;

Zhang, Jin Li ;

Xu, En ;

Cheng, Yan ;

Heritier, Stephan ;

Morgenstern, Lewis B. ;

Chalmers, John .

LANCET NEUROLOGY, 2008, 7 (05) :391-399

[5] Rapid Blood-Pressure Lowering in Patients with Acute Intracerebral Hemorrhage [J].

Anderson, Craig S. ;

Heeley, Emma ;

Huang, Yining ;

Wang, Jiguang ;

Stapf, Christian ;

Delcourt, Candice ;

Lindley, Richard ;

Robinson, Thompson ;

Lavados, Pablo ;

Neal, Bruce ;

Hata, Jun ;

Arima, Hisatomi ;

Parsons, Mark ;

Li, Yuechun ;

Wang, Jinchao ;

Heritier, Stephane ;

Li, Qiang ;

Woodward, Mark ;

Simes, R. John ;

Davis, Stephen M. ;

Chalmers, John .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (25) :2355-2365

[6]

[Anonymous], 1995, NEW ENGL J MED, V333, P1581, DOI [10.1056/NEJM199512143332401, DOI 10.1056/NEJM199512143332401]

[7] Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials [J].

Bath, Philip M. W. .

STROKE, 2007, 38 (06) :1911-1915

[8] Statistical Analysis of the Primary Outcome in Acute Stroke Trials [J].

Bath, Philip M. W. ;

Lees, Kennedy R. ;

Schellinger, Peter D. ;

Altman, Hernan ;

Bland, Martin ;

Hogg, Cheryl ;

Howard, George ;

Saver, Jeffrey L. .

STROKE, 2012, 43 (04) :1171-1178

[9] Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial [J].

Bracard, Serge ;

Ducrocq, Xavier ;

Mas, Jean Louis ;

Soudant, Marc ;

Oppenheim, Catherine ;

Moulin, Thieriy ;

Guillemin, Francis .

LANCET NEUROLOGY, 2016, 15 (11) :1138-1147

[10] Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke [J].

Broderick, Joseph P. ;

Palesch, Yuko Y. ;

Demchuk, Andrew M. ;

Yeatts, Sharon D. ;

Khatri, Pooja ;

Hill, Michael D. ;

Jauch, Edward C. ;

Jovin, Tudor G. ;

Yan, Bernard ;

Silver, Frank L. ;

von Kummer, Ruediger ;

Molina, Carlos A. ;

Demaerschalk, Bart M. ;

Budzik, Ronald ;

Clark, Wayne M. ;

Zaidat, Osama O. ;

Malisch, Tim W. ;

Goyal, Mayank ;

Schonewille, Wouter J. ;

Mazighi, Mikael ;

Engelter, Stefan T. ;

Anderson, Craig ;

Spilker, Judith ;

Carrozzella, Janice ;

Ryckborst, Karla J. ;

Janis, L. Scott ;

Martin, Renee H. ;

Foster, Lydia D. ;

Tomsick, Thomas A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (10) :893-903

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