Triple stimuli-responsive polymers based on pyrene-functionalized poly(dimethylaminoethyl methacrylate): synthesis, self-assembled nanoparticles and controlled release

被引：9
|
作者：
Dong, Jie [1 ]
Zhang, Ruichen [1 ]
Zhan, Xiaowei [2 ]
Yang, Huai [2 ]
Zhu, Siquan [3 ]
Wang, Guojie [1 ]
机构：
[1] Univ Sci & Technol Beijing, Sch Mat Sci & Engn, Beijing 100083, Peoples R China
[2] Peking Univ, Dept Mat Sci & Engn, Coll Engn, Beijing 100871, Peoples R China
[3] Capital Med Univ, Beijing Tongren Hosp, Beijing 100069, Peoples R China
来源：
COLLOID AND POLYMER SCIENCE | 2014年 / 292卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Polymers; Self-assembly; Stimuli-responsive; BLOCK-COPOLYMER MICELLES; DRUG-DELIVERY; RAFT POLYMERIZATION; REVERSE MICELLES; CLICK CHEMISTRY; GENE DELIVERY; PH; LIGHT; AZOBENZENE; VESICLES;
D O I：
10.1007/s00396-014-3358-x
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A series of photo, temperature, and pH-responsive polymers have been synthesized by the quaternization of poly(dimethylaminoethyl methacrylate) (PDMAEMA) with 1-(bromomethyl)pyrene. Nanoparticles self-assembled from the pyrene-functionalized polymers in aqueous solution are demonstrated by transmission electron microscopy (TEM) and dynamic light scattering (DLS), the morphology of which can be changed under external stimulation by UV light, temperature, and pH. With the increase of the functionalization degree, the lower critical solution temperature (LCST) and the photo response of the pyrene-functionalized polymer increases, while the critical aggregation concentration (CAC) and the pH response decreases. The controlled release of encapsulated molecules such as Nile Red (NR)and anticancer drug doxorubicin (DOX) can be achieved under the triple stimulation from the self-assembled nanoparticles.
引用
收藏
页码：2735 / 2744
页数：10
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