Macrocyclic diterpenoids from Euphorbia hyberna L. subsp insularis and their reaction with oxyphilic reagents

被引：25
作者：
Appendino, G
Spagliardi, P
Ballero, M
Seu, G
机构：
[1] Dipartimento Sci Chim Alimentari Farmaceut & Farm, I-28100 Novara, Italy
[2] Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy
[3] Dipartimento Sci Bot, I-09123 Cagliari, Italy
[4] Dipartimento Chim Inorgan & Analit, I-09042 Monserrato, CA, Italy
来源：
FITOTERAPIA | 2002年 / 73卷 / 7-8期
关键词：
Euphorbia hyberna subsp insularis; diterpenoids; jatrophanes; phorboids; chemotaxonomy;
D O I：
10.1016/S0367-326X(02)00213-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The aerial parts of Euphorbia hyberna subsp. insularis from Sardinia contain large amounts of macrocyclic diterpenoids of the jatrophane type, while phorboids could not be isolated. Treatment of the major constituent (1a) with various acidic and oxyphilic reagents was investigated, showing the surprising reluctance of the macrocyclic system to undergo transannular reactions. Dehydration, isomerization of the exocyclic double and acyl rearrangement were, however, observed after reduction of the 9-keto group. (C) 2002 Elsevier Science B.V. All rights reserved.
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收藏
页码：576 / 582
页数：7
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