The use of botulinum toxin for the treatment of muscle spasticity in the first 2 years of life

被引：7
作者：
Bakheit, Abdel Magid [1 ]
机构：
[1] Mt Gould Hosp, Plymouth PL4 7QD, Devon, England
来源：
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH | 2010年 / 33卷 / 02期
关键词：
botulinum toxin; childhood; muscle spasticity; PLACEBO-CONTROLLED TRIAL; CEREBRAL-PALSY; CORTICOSPINAL PROJECTIONS; LOWER-EXTREMITIES; GROWING RABBITS; MACAQUE MONKEY; DOUBLE-BLIND; CHILDREN; BONE; CONTRACTURES;
D O I：
10.1097/MRR.0b013e32832c1e91
中图分类号：
R49 [康复医学];
学科分类号：
100215 ;
摘要：
Although there are sound theoretical reasons for the use of botulinum toxin (Btx) as early as possible in the management of severe childhood muscle spasticity, the experience with its safety in children younger than 2 years of age is limited and information about its possible effects on the development and maturation of the human motor system is still scarce. This study discusses the rationale and the potential pitfalls of the use of Btx in the first 2 years of the child's life. It also reviews the currently available evidence on the efficacy and safety of Btx in this age group. It concludes by suggesting a framework for studies of the optimal time to start treatment of childhood spasticity with Btx. International Journal of Rehabilitation Research 33:104-108 (C) 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.
引用
收藏
页码：104 / 108
页数：5
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