The making of the mitotic chromosome: Modern insights into classical questions

被引：219
作者：
Swedlow, JR
Hirano, T [1 ]
机构：
[1] Univ Dundee, Div Gene Regulat & Express, Dundee DD1 5EH, Scotland
[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
MOLECULAR CELL | 2003年 / 11卷 / 03期
基金：
英国惠康基金; 美国国家卫生研究院;
关键词：
D O I：
10.1016/S1097-2765(03)00103-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.
引用
收藏
页码：557 / 569
页数：13
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