Asymmetric hydrogenation of a 4,4-diaryl-3-butenoate; a novel approach to sertraline

被引：27

作者：

Boulton, LT ^{[1
]}

Lennon, IC ^{[1
]}

McCague, R ^{[1
]}

机构：

[1] Chirotech Technol Ltd, Dowpharma, Cambridge CB4 0WG, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 07期

关键词：

D O I：

10.1039/b301175p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric hydrogenation of a selectively crystallised (E)-4,4-diaryl-3-butenoate with a rhodium-PhanePhos catalyst is described, providing an intermediate to the antidepressant sertraline.

引用

页码：1094 / 1096

页数：3

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