Stereoselective synthesis of the C14-C24 degraded fragment of symbiodinolide

被引：10

作者：

Takamura, Hiroyoshi ^{[1
]}

Kadonaga, Yuichiro ^{[1
]}

Kadota, Isao ^{[1
]}

Uemura, Daisuke ^{[2
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biochem, Kita Ku, Okayama 7008530, Japan

[2] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 19期

基金：

日本学术振兴会;

关键词：

Polyol macrolide; Symbiodinolide; Stereoselective synthesis; Structural confirmation; ASYMMETRIC ALDOL ADDITIONS; ABSOLUTE-CONFIGURATION; TITANIUM TETRACHLORIDE; SECONDARY ALCOHOLS; C33-C42; FRAGMENT; ALDEHYDES; OXIDATION; CONVERSION; EFFICIENT; AMIDES;

D O I：

10.1016/j.tetlet.2010.03.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Symbiodinolide is a polyol macrolide isolated from the marine dinoflagellate Symbiodinium sp. in 2007. The C14-C24 fragment of symbiodinolide possessing the 17R/18R/21R absolute configuration, which was obtained as one of the degraded products of symbiodinolide, was synthesized stereoselectively from cis-2-butene-1,4-diol. The detailed comparison of the synthetic product with the degraded product in the spectroscopic data confirmed that the stereostructure of the C14-C24 fragment was 17R, 18R, and 21R. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2603 / 2605

页数：3

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