Toll-dependent and Toll-independent immune responses in Drosophila

被引：30

作者：

Imler, JL ^{[1
]}

Ferrandon, D ^{[1
]}

Royet, J ^{[1
]}

Reichhart, JM ^{[1
]}

Hetru, C ^{[1
]}

Hoffmann, JA ^{[1
]}

机构：

[1] Inst Biol Mol & Cellulaire, CNRS, UPR 9022, F-67084 Strasbourg, France

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2004年 / 10卷 / 04期

关键词：

Toll; peptidoglycan recognition protein; Gram-negative binding protein; beta-glucan; recognition protein; pattern recognition receptor;

D O I：

10.1179/096805104225005887

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The multifaceted response of the fruitfly Drosophila melanogaster to infection by a wide range of microbes is complex and remarkably efficient. Its most prominent aspect is the immune-inducible expression of a set of potent antimicrobial peptides. Genetic analysis of the regulation of the genes encoding these peptides has led to the identification of the receptor Toll as an essential component of the fly's host defense system. In addition, these studies have revealed that the response to Gram-negative bacterial infections involves Toll-independent mechanisms, and that the sensing of infection involves two structurally distinct sets of molecules - the PGRPs and the GNBPs/GRPs.

引用

页码：241 / 246

页数：6

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