Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor type III polyketide synthases

被引：31
作者：
Gruschow, Sabine
Buchholz, Tonia J.
Seufert, Wolfgang
Dordick, Jonathan S.
Sherman, David H.
机构：
[1] Univ Michigan, Chem Biol Program, Dept Med Chem, Life Sci Inst, Ann Arbor, MI 48109 USA
[2] Rensselaer Polytech Inst, Dept Chem & Biol Engn, Troy, NY 12180 USA
来源：
CHEMBIOCHEM | 2007年 / 8卷 / 08期
关键词：
acyl carrier protein; biosynthesis; natural products; polyketides; pyrones;
D O I：
10.1002/cbic.200700026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
(Figure Presented) Protein partners. We report the biochemical characterization of two type III polyketide synthases (PKS) from Streptomyces coelicolor. Remarkably, germicidin synthase (Gcs)/SCO7221 was able to utilize both acyl-CoA and acyl-ACP as starter units for the production of pyrone containing compounds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：863 / 868
页数：6
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