Dual-Phase 18F-FP-CIT PET in 2 Different Clinical Phenotypes of Sporadic Creutzfeldt-Jakob Disease

被引：2

作者：

Lee, Keun ^{[1
]}

Park, Dong Gueu ^{[1
]}

Kim, Min Seung ^{[1
]}

An, Young Sil ^{[2
]}

Yoon, Jung Han ^{[1
]}

机构：

[1] Ajou Univ, Sch Med, Dept Neurol, Suwon, South Korea

[2] Ajou Univ, Sch Med, Dept Nucl Med, Suwon, South Korea

来源：

CLINICAL NUCLEAR MEDICINE | 2022年 / 47卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Creutzfeldt-Jakob disease; corticobasal syndrome; Heidenhain variant; dual; F-18-FP-CIT; MRI; DWI; FDG PET; CJD;

D O I：

10.1097/RLU.0000000000004240

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Early diagnosis of Creutzfeldt-Jakob disease (CJD) patients is often challenging due to the low sensitivity of the current clinical diagnostic criteria. We describe MRI and dual-phase 18F-FP-CIT PET findings in 2 cases of sporadic CJD presenting different clinical phenotypes (Heidenhain variant and corticobasal syndrome). Our case series suggest that dual-phase FP-CIT-PET findings may improve the diagnosis of CJD by combining the perfusion patterns in early phase with the dopamine transporter density in delayed phase. Familiarity with these dual-phase FP-CIT PET findings is helpful for early correct diagnosis of CJD. © 2022 Wolters Kluwer Health, Inc.

引用

页码：E548 / E549

页数：2