Advanced Nanocomposite Hydrogels for Cartilage Tissue Engineering

被引：29
作者：
Huang, Jianghong [1 ,2 ]
Liu, Fei [3 ]
Su, Haijing [4 ]
Xiong, Jianyi [1 ]
Yang, Lei [1 ]
Xia, Jiang [5 ]
Liang, Yujie [6 ]
机构：
[1] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Hlth Sci Ctr,Dept Spine Surg & Orthoped, Shenzhen 518035, Peoples R China
[2] Tsinghua Univ, Shenzhen Int Grad Sch, Shenzhen 518055, Peoples R China
[3] Texas A&M Univ, Sch Med, Dept Biochem, Bryan, TX 77807 USA
[4] Shenzhen Lechuang Med Res Inst Co Ltd, Technol R&D Dept, Shenzhen 518129, Peoples R China
[5] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
[6] Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen 518020, Peoples R China
来源：
GELS | 2022年 / 8卷 / 02期
关键词：
hydrogels; nanocomposite hydrogels; articular cartilage; tissue engineering; CHONDROGENIC DIFFERENTIATION; TOP-STEREOLITHOGRAPHY; POLYMERIC HYDROGELS; COMPOSITE-MATERIALS; SCAFFOLDS; DELIVERY; REPAIR; NANOMATERIALS; DEFECT; CELLS;
D O I：
10.3390/gels8020138
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Tissue engineering is becoming an effective strategy for repairing cartilage damage. Synthesized nanocomposite hydrogels mimic the structure of natural cartilage extracellular matrices (ECMs), are biocompatible, and exhibit nano-bio effects in response to external stimuli. These inherent characteristics make nanocomposite hydrogels promising scaffold materials for cartilage tissue engineering. This review summarizes the advances made in the field of nanocomposite hydrogels for artificial cartilage. We discuss, in detail, their preparation methods and scope of application. The challenges involved for the application of hydrogel nanocomposites for cartilage repair are also highlighted.
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页数：21
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