Polyamines are rich and induces epigenetic change by inhibition of LSD1 in cancer stem-like cells

被引:0
|
作者
Tamari, Keisuke
Ishii, Hideshi
Konno, Masamitsu
Nishida, Naohiro
Koseki, Jun
Kawamoto, Koichi
Isohashi, Fumiaki
Doki, Yuichiro
Mori, Masaki
Ogawa, Kazuhiko
机构
关键词
D O I
10.1158/1538-7445.AM2017-4774
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4774
引用
收藏
页数:2
相关论文
共 50 条
  • [1] Polyamines control epigenetics in cancer stem cells through LSD1
    Keisuke, Tamari
    Hideshi, Ishii
    Masamitsu, Konno
    Ayumu, Asai
    Jun, Koseki
    Masayasu, Toratani
    Yuichiro, Doki
    Masaki, Mori
    Kazuhiko, Ogawa
    CANCER SCIENCE, 2018, 109 : 273 - 273
  • [2] Inhibition of LSD1 for the treatment of cancer
    Smitheman, Kimberly
    Cusan, Monica
    Liu, Yan
    Butticello, Michael
    Pappalardi, Melissa
    Foley, James
    Federowicz, Kelly
    Van Aller, Glenn
    Kasparec, Jiri
    Tian, Xinrong
    Suarez, Dominic
    Schneck, Jess
    Carson, Jeff
    McDevitt, Patrick
    Ho, Thau
    McHugh, Charles
    Miller, William
    Armstrong, Scott
    Hann, Christine
    Johnson, Neil
    Kruger, Ryan G.
    Mohammad, Helai P.
    Kamat, Shekhar
    CANCER RESEARCH, 2015, 75
  • [3] LSD1 inhibition: a therapeutic strategy in cancer?
    Lynch, James T.
    Harris, William J.
    Somervaille, Tim C. P.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2012, 16 (12) : 1239 - 1249
  • [4] Effect of LSD1 inhibition on intracellular metabolism in pancreatic cancer cells
    Aoki, Haruna
    Miyazaki, Natsumi
    Oshima, Taichi
    Aoki, Shigeki
    CANCER SCIENCE, 2022, 113 : 1682 - 1682
  • [5] Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition
    Stewart, C. Allison
    Byers, Lauren Averett
    CANCER CELL, 2015, 28 (01) : 4 - 6
  • [6] Pharmacological Inhibition of LSD1 for Cancer Treatment
    Yang, Guan-Jun
    Lei, Pui-Man
    Wong, Suk-Yu
    Ma, Dik-Lung
    Leung, Chung-Hang
    MOLECULES, 2018, 23 (12):
  • [7] LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem-like Cells
    Liu, Chungang
    Liu, Limei
    Chen, Xuejiao
    Cheng, Jiamin
    Zhang, Heng
    Zhang, Chengcheng
    Shan, Juanjuan
    Shen, Junjie
    Qian, Cheng
    CANCER RESEARCH, 2018, 78 (04) : 938 - 949
  • [8] Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
    Tinka Haydn
    Eric Metzger
    Roland Schuele
    Simone Fulda
    Cell Death & Disease, 2017, 8 : e2879 - e2879
  • [9] INCB059872, a novel FAD-directed LSD1 Inhibitor, is active in prostate cancer models and impacts prostate cancer stem-like cells
    Civenni, Gianluca
    Zoppi, Giada
    Vazquez, Ramiro
    Shinde, Dhreeraj
    Paganoni, Alyssa
    Kokanovic, Aleksandra
    Lee, Sang Hyun
    Ruggeri, Bruce
    Carbone, Giuseppina M.
    Catapano, Carlo V.
    CANCER RESEARCH, 2018, 78 (13)
  • [10] Concomitant epigenetic targeting of LSD1 and HDAC synergistically induces mitochondrial apoptosis in rhabdomyosarcoma cells
    Haydn, Tinka
    Metzger, Eric
    Schuele, Roland
    Fulda, Simone
    CELL DEATH & DISEASE, 2017, 8 : e2879 - e2879