Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

被引：57

作者：

Han, Yiwen ^{[1
,2
]}

Liu, Zhaoxia ^{[1
]}

Chen, Tingtao ^{[1
,3
]}

机构：

[1] Nanchang Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Nanchang, Jiangxi, Peoples R China

[2] Nanchang Univ, Queen Mary Sch, Nanchang, Jiangxi, Peoples R China

[3] Nanchang Univ, Natl Engn Res Ctr Bioengn Drugs & Technol, Inst Translat Med, Nanchang, Jiangxi, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

vaginal microbiota transplantation; bacterial vaginitis; antibiotics; Lactobacillus; gynecological diseases; SIMPLEX-VIRUS TYPE-2; CERVICAL INTRAEPITHELIAL NEOPLASIA; BACTERIAL VAGINOSIS; LACTOBACILLUS-CRISPATUS; MYCOPLASMA-GENITALIUM; RISK-FACTORS; WOMEN; INFECTION; HEALTH; ASSOCIATION;

D O I：

10.3389/fmicb.2021.643422

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.

引用

页数：11

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