Formulation of oil-in-water β-carotene microemulsions: Effect of oil type and fatty acid chain length

被引：81

作者：

Roohinejad, Shahin ^{[1
]}

Oey, Indrawati ^{[1
]}

Wen, Jingyuan ^{[2
]}

Lee, Sung Je ^{[3
]}

Everett, David W. ^{[1
,5
]}

Burritt, David J. ^{[4
]}

机构：

[1] Univ Otago, Dept Food Sci, Dunedin, New Zealand

[2] Univ Auckland, Sch Pharm, Auckland 1, New Zealand

[3] Massey Univ, Inst Food Nutr & Human Hlth, Auckland, New Zealand

[4] Univ Otago, Dept Bot, Dunedin, New Zealand

[5] Riddet Inst, Palmerston North, New Zealand

来源：

FOOD CHEMISTRY | 2015年 / 174卷

关键词：

beta-Carotene microemulsion; Phase diagrams; Medium-chain fatty acids; Monoglycerides; Non-ionic surfactant; Cytotoxicity test; LUNG-CANCER; DELIVERY; SOLUBILIZATION; SURFACTANTS; EMULSIONS; TRANSPORT; CELLS; FOOD;

D O I：

10.1016/j.foodchem.2014.11.056

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The impact of oil type and fatty acid chain length on the development of food-grade microemulsions for the entrapment of beta-carotene was investigated. The microemulsion region of a ternary phase diagram containing short chain monoglycerides was larger than for di- and triglycerides when Tween 80 was used as surfactant. The cytotoxicity of microemulsions composed of a 30% monoglyceride oil, 20% Tween 80 and 50% aqueous buffer were evaluated using an in vitro cell culture model (human epithelial colorectal adenocarcinoma, Caco-2). The cytotoxicity test showed that the viability of Caco-2 cells against beta-carotene microemulsions at concentrations of 0.03125% (v/v) was higher than 90%. This study suggests that short chain monoglycerides could be used with Tween 80 to prepare transparent beta-carotene-encapsulated O/W microemulsions in the particle size range of 12-100 nm. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：270 / 278

页数：9

共 32 条

[1] alpha-tocopherol and beta-carotene supplements and lung cancer incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Effects of base-line characteristics and study compliance [J].