Influence of nanoscale surface topography on protein adsorption and cellular response

被引：526
作者：
Lord, Megan S. [3 ]
Foss, Morten [1 ,2 ]
Besenbacher, Flemming [1 ,2 ]
机构：
[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark
[2] Aarhus Univ, Dept Phys & Astron, DK-8000 Aarhus C, Denmark
[3] Univ New S Wales, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
来源：
NANO TODAY | 2010年 / 5卷 / 01期
关键词：
Nanoscale surface topography (nanotopography); Protein adsorption; Cellular response; SILICA NANOPARTICULATE COATINGS; ENHANCED OSTEOBLAST ADHESION; OSTEOPROGENITOR RESPONSE; NANOMETER-SCALE; IMPRINT LITHOGRAPHY; FIBROBLAST RESPONSE; CONTACT GUIDANCE; THIN-FILMS; CELLS; NANOTOPOGRAPHY;
D O I：
10.1016/j.nantod.2010.01.001
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The nanoscale surface topography of artificial materials is known to play a significant role in interactions with biological, systems such as proteins and cells. A detailed understanding, and ultimately control, of these interactions is therefore of utmost importance in areas such as cell culture technology, biosensing and medical device development. We briefly review different methods to synthesise and fabricate surfaces with well-defined nanoscale topography, and discuss how such nanostructured surfaces can be used as model systems in protein and cellular assays. Finally, an outlook of possible future in vitro and in vivo developments is provided. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：66 / 78
页数：13
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