Galectin-3 is associated with glomerular filtration rate and outcome in patients with stable decompensated cirrhosis

被引:6
作者
Oikonomou, Theodora [1 ]
Goulis, Ioannis [1 ]
Ntogramatzi, Fani [2 ]
Athanasiadou, Zoi [2 ]
Vagdatli, Eleni [2 ]
Akriviadis, Evangelos [1 ]
Cholongitas, Evangelos [3 ]
机构
[1] Aristotle Univ Thessaloniki, Sch Med, Hippokrat Gen Hosp, Dept Internal Med 4, Thessaloniki 54642, Greece
[2] Hippokrateion Hosp, Dept Biochem, Thessaloniki 54642, Greece
[3] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Internal Med 1, Agiou Thoma 17, Athens 11527, Greece
关键词
Decompensated cirrhosis; Galectin-3; Kidney; Renal function; Liver; Cirrhosis; Prognosis; LIVER; SURVIVAL; MODEL;
D O I
10.1016/j.dld.2019.05.030
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: Newly introduced galectin-3 (gal-3) has been associated to impaired renal function. Gal-3 may become prognostic biomarker in hepatic diseases. Aim: To investigate the association of gal-3 with prognosis and renal function in patients with stable decompensated cirrhosis. Method: We studied prospectively 100 stable decompensated patients in our Department between 2010 and 2017. We measured gal-3 in serum samples. Patients' renal function was assessed using (51)Chromium-EDTA ("true GFR"). Results: Seventy patients (70%) survived and 30 died (n = 16) or underwent LT (n = 14). Twenty nine patients (29%) had normal gal-3, 71 (71%) had >= 11.7 ng/mL; they differed significantly regarding mean "true"-GFR: 90 +/- 20 mL/min vs. 76 +/- 26 mL/min, p = 0.03 and mean creatinine: 0.83 +/- 0.14 mg/dL vs. 0.97 +/- 0.4 mg/dL, p = 0.05. Median gal-3 levels were 17.5 ng/mL (range 4.9-76.5 ng/mL); 49 patients with gal-3 >= 17.5 ng/mL had significantly higher MELD score, (15 +/- 5 vs. 13 +/- 4, p = 0.02) and worse "true" GFR (74 vs. 85 mL/min, p = 0.04). Gal-3 had good performance in predicting "true"-GFR < 60 mL/min; AUC: 0.71, 95%CI [0.58-0.85], best cut off value 17.5 ng/mL. Kaplan-Meier analysis, using median gal-3 (17.5 ng/mL) revealed different survival time for our patients (log-rank p = 0.04). Conclusion: Gal-3 proved trustworthy marker of established chronic kidney disease, with predictive ability in stable decompensated cirrhosis. Gal-3 came also a significant factor for our patients' outcome. (c) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1692 / 1697
页数:6
相关论文
共 22 条
[1]  
[Anonymous], PLOS ONE
[2]  
[Anonymous], HEPATOL RES
[3]  
[Anonymous], INT J MOL SCI
[4]  
[Anonymous], 2018, SCI REP
[5]   Galectin-3-binding protein: a serological and histological assessment in accordance with hepatitis C-related liver fibrosis [J].
Cheung, Kin Jip ;
Libbrecht, Louis ;
Tilleman, Kelly ;
Deforce, Dieter ;
Colle, Isabelle ;
Van Vlierberghe, Hans .
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2010, 22 (09) :1066-1073
[6]   Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies [J].
D'Amico, G ;
Garcia-Tsao, G ;
Pagliaro, L .
JOURNAL OF HEPATOLOGY, 2006, 44 (01) :217-231
[7]   Pitfalls in assessing renal function in patients with cirrhosis-potential inequity for access to treatment of hepatorenal failure and liver transplantation [J].
Davenport, Andrew ;
Cholongitas, Evangelos ;
Xirouchakis, Elias ;
Burroughs, Andrew Kenneth .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (09) :2735-2742
[8]   Assessment of prognosis of cirrhosis [J].
Durand, Francois ;
Valla, Dominique .
SEMINARS IN LIVER DISEASE, 2008, 28 (01) :110-122
[9]   The new BNMS guidelines for glomerular filtration rate measurement of glomerular filtration rate [J].
Fleming, JS ;
Nunan, TO .
NUCLEAR MEDICINE COMMUNICATIONS, 2004, 25 (08) :755-757
[10]   Galectin 3: association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure [J].
Gaborit, Freja Stoltze ;
Bosselmann, Helle ;
Kistorp, Caroline ;
Iversen, Kasper ;
Kumler, Thomas ;
Gustafsson, Finn ;
Goetze, Jens P. ;
Soletormos, Gyorgy ;
Tonder, Niels ;
Schou, Morten .
BMC CARDIOVASCULAR DISORDERS, 2016, 16