Pomegranate extract inhibits Staphylococcus aureus growth and subsequent enterotoxin production

被引：165

作者：

Braga, LC

Shupp, JW

Cummings, C

Jett, M

Takahashi, JA

Carmo, LS

Chartone-Souza, E

Nascimento, AMA ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, Belo Horizonte, MG, Brazil

[2] Walter Reed Army Inst Res, Div Pathol, Dept Mol Pathol, Silver Spring, MD 20910 USA

[3] Univ Fed Minas Gerais, Inst Ciencias Exatas, Dept Quim, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2005年 / 96卷 / 1-2期

关键词：

Punica granatum; Staphylococcus aureus; Staphylococcal enterotoxin A;

D O I：

10.1016/j.jep.2004.08.034

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In Brazil, pomegranate (Punica granatum L. (Punicaceae)) is widely used as a phytotherapeutic agent. This study evaluates the effect of pomegranate extract on Staphylococcus aureus FRI 722 growth and subsequent enterotoxin production. Bacterial susceptibility was determined by tube dilution method and production of enterotoxin was assessed using membrane-over-agar (MOA) plates. At a low extract concentration (0.01% v/v) bacterial growth was delayed, while a higher concentration (1% v/v) eliminated bacterial growth. Most interestingly, a 0.05% (v/v) concentration of extract was found to inhibit Staphylococcal enterotoxin (SE) A production. These data further implicate pomegranate extracts as potential antibacterial therapeutics with the added ability to inhibit enterotoxin production. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：335 / 339

页数：5

共 24 条

[1] Staphylococcal enterotoxins [J].