99mTc-MIBI, 99mTc-tetrofosmin and 99mTc-Q12 in vitro and in vivo

被引：48
作者：
Bernard, BF
Krenning, EP
Breeman, WAP
Ensing, G
Benjamins, H
Bakker, WH
Visser, TJ
de Jong, M
机构：
[1] Univ Hosp Dijkzigt, Dept Nucl Med, NL-3015 GD Rotterdam, Netherlands
[2] Univ Hosp Dijkzigt, Dept Internal Med 3, NL-3015 GD Rotterdam, Netherlands
[3] Erasmus Univ, Sch Med, Rotterdam, Netherlands
[4] Mallinckrodt Med, Petten, Netherlands
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1998年 / 25卷 / 03期
关键词：
Tc-99m-MIBI; Tc-99m-tetrofosmin; Tc-99m-Q12; tumor; uptake; biodistribution;
D O I：
10.1016/S0969-8051(97)00201-1
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The aim of this study was to compare uptake of Tc-99m-MIBI, Tc-99m-tetrofosmin and Tc-99m-Q12 in vitro and biodistribution in vivo in rats. In vitro, uptake decreased in the order MIBI-->tetrofosmin-->Q12. Uptake of MIBI and tetrofosmin, but not of Q12, in cultured tumor cells was dependent on the plasma membrane and mitochondrial potential. In vivo, heart uptake of all three compounds was high and stable. Tumor uptake decreased in the order MIBI-->Q12-->tetrofosmin and the tumor/blood ratio in the order MIBI-->tetrofosmin-->Ql2. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：233 / 240
页数：8
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