Thyroid hormones and cardiac arrhythmias

被引：59
作者：
Tribulova, Narcis [1 ]
Knezl, Vladimir [2 ]
Shainberg, Asher [3 ]
Seki, Shingo [4 ]
Soukup, Tomas [5 ]
机构：
[1] Slovak Acad Sci, Heart Res Inst, Dubravska Cesta 9,POB 104, Bratislava 84005, Slovakia
[2] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Bratislava 84005, Slovakia
[3] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel
[4] Jikei Univ, Dept Internal Med, Div Cardiol, Tokyo, Japan
[5] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic
来源：
VASCULAR PHARMACOLOGY | 2010年 / 52卷 / 3-4期
关键词：
Thyroid hormone; Arrhythmias; Ion channels; Connexin-43; Ca2+ handling; PROTEIN-KINASE-C; ATRIAL-FIBRILLATION; VENTRICULAR-FIBRILLATION; GENE-EXPRESSION; RISK-FACTOR; SUBCLINICAL HYPERTHYROIDISM; MYOCARDIAL-INFARCTION; EPSILON EXPRESSION; POTASSIUM CHANNELS; CALCIUM OVERLOAD;
D O I：
10.1016/j.vph.2009.10.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Thyroid hormone plays an important role in cardiac electrophysiology and Ca2+ handling through both genomic and nongenomic mechanisms of action, while both actions can interfere. Chronic changes in the amount of circulating thyroid hormone due to thyroid dysfunction or systemic disease result in structural, electrophysiological and Ca2+ handling remodeling, while acute changes may affect basal activity of cardiac cells membrane systems. Consequently, long-term or rapid modulation of sarcolemmal ion channels, Ca2+ cycling proteins and intercellular communicating channels by thyroid hormone may affect heart function as well as susceptibility of the heart to arrhythmias. This aspect including pro- and anti-arrhythmic potential of thyroid hormone is highlighted in this review. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：102 / 112
页数：11
相关论文
共 174 条
  • [71] EFFECTS OF THYROID-HORMONE ON CALCIUM HANDLING IN CULTURED CHICK VENTRICULAR CELLS
    KIM, D
    SMITH, TW
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1985, 364 (JUL): : 131 - 149
  • [72] THYROID HORMONE-INDUCED ALTERATIONS IN PHOSPHOLAMBAN PROTEIN EXPRESSION - REGULATORY EFFECTS ON SARCOPLASMIC-RETICULUM CA2+ TRANSPORT AND MYOCARDIAL RELAXATION
    KISS, E
    JAKAB, G
    KRANIAS, EG
    EDES, I
    [J]. CIRCULATION RESEARCH, 1994, 75 (02) : 245 - 251
  • [73] KLEBER G, 1992, BASIC RES CARDIOL, V87, P131
  • [74] Klein I, 2000, LANCET, V356, P614
  • [75] KLEIN L, 2001, N ENGL MED, V344, P503
  • [76] Triiodothyronine therapy lowers the incidence of atrial fibrillation after cardiac operations
    Klemperer, JD
    Klein, IL
    Ojamaa, K
    Helm, RE
    Gomez, M
    Isom, W
    Krieger, KH
    [J]. ANNALS OF THORACIC SURGERY, 1996, 61 (05) : 1323 - 1327
  • [77] Thyroid hormone and cardiac surgery
    Klemperer, JD
    [J]. THYROID, 2002, 12 (06) : 517 - 521
  • [78] Thyroid Hormones Modulate Occurrence and Termination of Ventricular Fibrillation by both Long-Term and Acute Actions
    Knezl, V.
    Soukup, T.
    Okruhlicova, L'.
    Slezak, J.
    Tribulova, N.
    [J]. PHYSIOLOGICAL RESEARCH, 2008, 57 : S91 - S96
  • [79] Atrial fibrillation in elderly patients after cardiac surgery:: Postoperative hemodynamics and low postoperative serum triiodothyronine
    Kokkonen, L
    Majahalme, S
    Kööbi, T
    Virtanen, V
    Salmi, J
    Huhtala, H
    Tarkka, M
    Mustonen, J
    [J]. JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2005, 19 (02) : 182 - 187
  • [80] REDUCED CARDIAC VAGAL EXCITABILITY IN HYPERTHYROIDISM
    KOLLAI, B
    KOLLAI, M
    [J]. BRAIN RESEARCH BULLETIN, 1988, 20 (06) : 785 - 790
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